Astrocytes restore connectivity and synchronization in dysfunctional cerebellar networks

Proceedings of the National Academy of Sciences of the United States of America
Sivan KannerAri Barzilai

Abstract

Evidence suggests that astrocytes play key roles in structural and functional organization of neuronal circuits. To understand how astrocytes influence the physiopathology of cerebellar circuits, we cultured cells from cerebella of mice that lack the ATM gene. Mutations in ATM are causative of the human cerebellar degenerative disease ataxia-telangiectasia. Cerebellar cultures grown from Atm -/- mice had disrupted network synchronization, atrophied astrocytic arborizations, reduced autophagy levels, and higher numbers of synapses per neuron than wild-type cultures. Chimeric circuitries composed of wild-type astrocytes and Atm -/- neurons were indistinguishable from wild-type cultures. Adult cerebellar characterizations confirmed disrupted astrocyte morphology, increased GABAergic synaptic markers, and reduced autophagy in Atm -/- compared with wild-type mice. These results indicate that astrocytes can impact neuronal circuits at levels ranging from synaptic expression to global dynamics.

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Citations

Oct 4, 2020·Nucleic Acids Research·Zhong-Wei ZhouZhao-Qi Wang
Mar 15, 2020·Journal of Clinical Medicine·Valentina Cerrato
Jan 27, 2021·The Journal of Comparative Neurology·Karthik RaviArumugam R Jayakumar
Aug 26, 2021·Nature Reviews. Molecular Cell Biology·Ji-Hoon Lee, Tanya T Paull
Dec 3, 2021·Glia·Hadar LeviAri Barzilai

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