PMID: 7539325Jan 1, 1995Paper

Astrocytes upregulate glial fibrillary acidic protein (GFAP), but not insulin-like growth factor-I (IGF-I) during experimental autoimmune neuritis (EAN)

Brain Pathology
J GehrmannH de F Webster

Abstract

T cell-mediated autoimmune neuritis produces rapid activation of spinal cord microglia. To determine whether this microglial response upregulates astrocytic expression of IGF-related proteins, we induced EAN and used in situ hybridization and immunocytochemistry to examine the mRNAs and peptides for glial fibrillary acidic protein (GFAP), insulin-like growth factor-I (IGF-I), IGF-I receptor (IGFR-I) and IGF binding protein-2 (IGFBP-2). Relative levels of GFAP mRNA and peptide were highest in the lumbar spinal cord 4-10 d following T cell transfer and significant GFAP elevations were still present after three weeks. The astrocytes expressing GFAP mRNA and peptide were localized around motoneurons which were related topographically to axons in peripheral nerve inflammatory lesions. In the nucleus gracilis, where terminals of dorsal root ganglion neurons are located, astrocytic levels of GFAP mRNA and peptide rose later and did not reach their highest levels until 21 d after T cell transfer. Even though microglia were activated in both locations 2-4 d after transfer, astrocytic levels of IGF-I, IGFR-I and IGFBP-2 mRNA and peptide did not differ significantly from those observed in controls. The dissociation of GFAP and IGF-I expre...Continue Reading

References

Mar 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·S KomolyC A Bondy
Oct 1, 1990·Experimental Neurology·A M Fagan, F H Gage
May 1, 1990·Brain Research. Molecular Brain Research·M BrennerE Freese
Nov 1, 1990·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·C K PetitoM L Lesser
Sep 6, 1990·Nature·P R Lennard
Oct 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·H WernerD LeRoith
Jun 22, 1989·The Journal of Comparative Neurology·H G GoshgarianJ A Rafols
Jan 1, 1968·Zeitschrift für Zellforschung und mikroskopische Anatomie·K Blinzinger, G Kreutzberg
Jun 1, 1994·Glia·Y Shao, K D McCarthy
May 1, 1994·Journal of Neuropathology and Experimental Neurology·M D Norenberg
Jan 1, 1993·Acta Neuropathologica·M B GraeberP Mehraein
Feb 1, 1992·Molecular and Cellular Neurosciences·W H LeeC A Bondy

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Citations

Feb 1, 1995·Muscle & Nerve·H P HartungK V Toyka
Mar 1, 1995·Brain Research. Brain Research Reviews·J GehrmannG W Kreutzberg
Aug 1, 1995·Neuropathology and Applied Neurobiology·J GehrmannG W Kreutzberg
Jun 5, 2002·Journal of Neuroimmunology·Tatiana I SamoylovaNancy R Cox
May 29, 2007·International Review of Neurobiology·Daniel ChesikJacques De Keyser
Jun 8, 2006·The Journal of Veterinary Medical Science·Ho Jae Han, Soo Hyun Park
Jun 1, 2004·Nutrition Research Reviews·Thomas C Vary, Christopher J Lynch

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