Astrocytic Ca2+ responses in the spinal dorsal horn by noxious stimuli to the skin

Journal of Pharmacological Sciences
Kohei YoshiharaMakoto Tsuda

Abstract

The role of astrocytes in the spinal dorsal horn (SDH) for sensory information processing under normal conditions is poorly understood. In this study, we investigated whether SDH astrocytes respond to noxious and innocuous stimuli to the skin of normal mice using in vivo two-photon Ca2+ imaging under anesthesia. We found that noxious stimulation evoked by intraplantar formalin injection provoked an elevation in intracellular Ca2+ levels in SDH astrocytes. By contrast, neither instantaneous noxious pinching nor innocuous stimuli (cooling or brushing) to the hindpaw elicited astrocytic Ca2+ responses. Thus, SDH astrocytes could respond preferentially to a strong and/or sustained noxious stimulus.

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Citations

Jul 1, 2020·Frontiers in Neural Circuits·Erika K HardingRobert P Bonin
Aug 12, 2020·The Journal of Allergy and Clinical Immunology·Miho Shiratori-HayashiMakoto Tsuda
Mar 12, 2019·Experimental Neurology·Qian Xu, Xinzhong Dong
Nov 4, 2021·Science Advances·Qian XuXinzhong Dong

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