Astrocytic changes in the hippocampus and functional recovery after cerebral ischemia are facilitated by rehabilitation training

Behavioural Brain Research
Teresita L BrionesMai Nguyen

Abstract

In this study we examined whether astrocytic and basic fibroblast growth factor changes after cerebral ischemia can be influenced by rehabilitation training and if these changes are associated with functional improvement. After receiving either ischemia or sham surgery, male adult Wistar rats were assigned to one of two rehabilitation training group: complex environment housing (EC) or paired housing as controls (CON). Rats were tested in the water maze after 14 days of rehabilitation training. Results showed increased expression of reactive astrocytes (GFAP) in all ischemic animals and in the sham EC rats with a significant overall increased seen in the ischemia EC housed animals. The pattern of basic fibroblast growth factor (FGF-2) expression seen was somewhat similar to that of GFAP. Behavioral data showed that even though all animals learned to perform the water maze task over time, the ischemia CON rats took longer to learn the task while all the ischemia EC animals performed as well as the sham groups. Regression analysis showed that increased GFAP was able to explain some of the variances in the behavioral parameters in the water maze of the ischemia EC rats suggesting that the activation of astrocytes in this group pro...Continue Reading

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Citations

Dec 12, 2013·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Xiaofang LanGuangqin Li
Oct 15, 2009·Physiology & Behavior·Giordano Gubert ViolaDiogo Onofre Souza
Jul 28, 2016·Molecular Therapy : the Journal of the American Society of Gene Therapy·Jung Hwa SeoSung-Rae Cho
Feb 26, 2016·Cellular and Molecular Neurobiology·Jingjing Nie, Xiaosu Yang
Oct 11, 2019·Journal of Neurotrauma·Justus BaeckerAndrea Kleindienst

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