Astrocytic pyruvate carboxylation: Status after 35 years

Journal of Neuroscience Research
Arne SchousboeUrsula Sonnewald

Abstract

The first two publications dealing with the question of the cellular localization of the enzyme pyruvate carboxylase (PC) which in the brain represents the most important metabolic pathway to allow anaplerosis of TCA cycle constituents were published in 1983 and 1985. Hence, 2018 marks the 35th anniversary of the notion based on the results of the publications provided above that PC-catalyzed anaplerosis in the brain is an astrocytic process. This review will provide the background for investigating this enzymatic pathway as well as a discussion of cataplerosis, the degradation of products from anaplerosis, and the current status of the functional significance of pyruvate carboxylation in brain metabolism.

References

Mar 25, 1977·Science·A Martinez-HernandezM D Norenberg
Mar 1, 1977·The Journal of Clinical Investigation·B HindfeltT E Duffy
Jan 1, 1992·Journal of Neurochemistry·E E Kaufman, B F Driscoll
Jun 1, 1985·Journal of Neurochemistry·A J CooperA S Gelbard
Feb 1, 1968·Journal of Neurochemistry·S BerlD D Clarke
Nov 1, 1983·Journal of Neurochemistry·A C YuA Schousboe
Apr 11, 1995·Proceedings of the National Academy of Sciences of the United States of America·N WestergaardA Schousboe
May 1, 1994·Journal of Neurochemistry·N WestergaardA Schousboe
Jan 1, 1996·Journal of Neurochemistry·M C McKennaH R Zielke
Mar 25, 1998·Journal of Neuroscience Research·I J BakkenU Sonnewald
Oct 21, 1998·Developmental Neuroscience·A HåbergU Sonnewald
Nov 17, 1999·Proceedings of the Society for Experimental Biology and Medicine·A S Hazell, R F Butterworth
Jan 5, 2000·Journal of the Neurological Sciences·J Albrecht, E A Jones
Dec 9, 2000·Developmental Neuroscience·P M AlvesH Santos
May 23, 2001·Progress in Neurobiology·N C Danbolt
Feb 27, 2003·Metabolic Brain Disease·Roger F Butterworth
Feb 28, 1959·Nature·D R CURTISJ C WATKINS
Dec 17, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Gülin OzRolf Gruetter
Jan 13, 2006·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Fahmeed HyderRobert G Shulman
Mar 16, 2006·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Torun M MeløAstrid Nehlig
Jun 24, 2008·The Medical Clinics of North America·Santiago J Munoz
Sep 16, 2010·Neurochemical Research·Ursula Sonnewald, Caroline Rae
Oct 1, 2010·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Saul W BrusilowArthur J L Cooper
Nov 11, 2010·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Leif Hertz
Dec 22, 2011·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Gerald A Dienel
May 16, 2013·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Sherry DadsetanHelle S Waagepetersen
Dec 19, 2013·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Andreas W FriesMichael Sørensen
Jan 1, 2014·Frontiers in Endocrinology·Mary C McKenna

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Citations

Nov 5, 2019·Molecular and Cellular Neurosciences·Kevin McAvoy, Hibiki Kawamata
Jul 18, 2021·Neuropharmacology·Jens V AndersenBlanca I Aldana
Aug 31, 2021·Current Opinion in Clinical Nutrition and Metabolic Care·Lubos Sobotka, Ondrej Sobotka
Jul 17, 2021·Annual Review of Nutrition·Melissa InigoShawn C Burgess
Jan 21, 2022·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Laura M McNairKevin L Behar

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