PMID: 7540218Feb 1, 1995Paper

Astrocytic reaction after graded spinal cord compression in rats: immunohistochemical studies on glial fibrillary acidic protein and vimentin

Journal of Neurotrauma
M FarooqueA Holtz

Abstract

The relation between the degree of spinal cord compression and the extent of early posttraumatic reaction of astrocytes was investigated in rats using the blocking-weight technique to induce a spinal cord compression at the level of the Th8-9. Immunohistochemistry was used to detect changes in the expression of glial fibrillary acidic protein (GFAP) and vimentin up to 24 h after injury. A mild compression, which did not cause any measurable neurological deterioration, induced a mild increase of GFAP immunoreactivity at 4 h and a more marked and widespread immunoreactivity at 24 h. The greatest increase of GFAP immunoreactive astrocytes occurred in rats with moderate compression of the cord causing reversible paraparesis and in animals with severe compression leading to paraplegia. The increase of GFAP immunoreactivity was present already 4 h after injury in virtually all the segments investigated (Th5-6-Th11-12) and was most marked at 24 h. Vimentin immunoreactivity of control rats was present in the ependymal cells of the central canal, the leptomeninges, and walls of a few intramedullary vessels. Occasional astrocytes were stained. In rats surviving 24 h after moderate and severe compression vimentin immunoreactivity was incr...Continue Reading

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Citations

Dec 1, 1996·Journal of the Neurological Sciences·N Y CalingasanJ P Blass
Jun 14, 2003·Journal of Neurotrauma·Enrique VerdúXavier Navarro
Aug 17, 2004·Journal of Neurotrauma·Hiroshi OzawaShoichi Kokubun
Jan 8, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sarah A BuschJerry Silver
Jan 19, 2006·Journal of Neurochemistry·Katsuaki YamauchiJun Yoshida
Apr 18, 2009·Cell Adhesion & Migration·Sei ShibuyaToshifumi Itano

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