Astrocytic responses in the lateral geniculate nucleus of monkeys with experimental glaucoma

Veterinary Ophthalmology
Yi DaiDao-Yi Yu


To investigate the responses of lateral geniculate nucleus (LGN) astrocytes to experimental glaucoma in monkeys. Rhesus monkeys (Macaca mulatta). Unilateral chronic elevation of intraocular pressure (IOP) was induced in six rhesus monkeys by laser photocoagulation of the trabecular meshwork. Four normal monkeys were used as controls. Immunohistochemistry with antibodies to glial fibrillary acidic protein (GFAP), S100β and parvalbumin was used to specifically label astrocytes and neurons in the LGN. The relative immunointensity (RI) of GFAP was defined as the ratio of intensity between each region of interest to a reference field and compared between the experimental and control groups as a function of percentage optic nerve fiber loss. Ultrastructural changes of LGN astrocytes were examined by transmission electron microscopy. An increase in GFAP and S100β immunoreactivity was observed in the LGN layers receiving projections from the experimental glaucoma eyes. Quantitative analysis revealed that the RI of GFAP in both the magnocellular and parvocellular layers connected to the glaucomatous eyes increased in a linear fashion with increasing optic nerve fiber loss. Compared to controls, the RI of GFAP was also moderately elevate...Continue Reading


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Related Concepts

Medial Geniculate Body
Macaca mulatta
Glial Fibrillary Acidic Protein
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