PMID: 8615085Jan 1, 1995Paper

Astroglial localization of cholesteryl ester transfer protein in normal and Alzheimer's disease brain tissues

Acta Neuropathologica
T YamadaT Sato

Abstract

Cholesteryl ester transfer protein (CETP) is a plasma glycoprotein that facilitates the transfer of cholesteryl esters, phospholipids and triglycerides between the lipoproteins, and regulates plasma high-density lipoprotein levels. We examined CETP-like immunolabeling in non-neurological and Alzheimer's disease (AD) liver and brain tissues. The anti-CETP antibodies showed positive staining in round cells in the liver sinusoid and in brain astrocytes. In the brains of non-neurological cases, positively stained astrocytes were preferentially distributed in the white matter. In AD tissue, many reactive astrocytes in the gray matter as well as the white matter astrocytes had CETP-like immunoreactivity. CETP-positive astrocytes may play a role for AD pathology such as tissue repair.

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Citations

Jan 14, 2010·JAMA : the Journal of the American Medical Association·Amy E SandersRichard B Lipton
May 16, 2007·Neurogenetics·Alejandro Arias-VásquezCornelia M van Duijn
Sep 6, 2011·Brain Imaging and Behavior·Elizabeth A MurphyUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Apr 7, 2011·Biological & Pharmaceutical Bulletin·Hideki Hayashi
Aug 19, 2014·Neurobiology of Disease·David A HottmanLing Li
May 9, 2006·Current Opinion in Lipidology·Xian-Cheng Jiang, Hong-Wen Zhou
Jan 6, 2010·Journal of Neurochemistry·Ian J MartinsRalph N Martins
Apr 14, 1999·Psychiatry and Clinical Neurosciences·K KosakaH Arai
Apr 13, 2001·Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi·S UesakaK Yoshihara
Sep 6, 2020·Journal of Neurochemistry·Steve PedriniRalph N Martins
Oct 6, 2021·ELife·Isabel GamacheJulie Hussin

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