Astroglial plasticity in hemizygous and heterozygous jimpy mice

International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience
T T BestW P Bartlett

Abstract

Gliosis is a common phenomenon which occurs in many human diseases and in experimentally altered nervous tissue. The factors activating astrocytes to respond are still unclear but recent evidence suggests that diverse substances can provoke a gliotic response. This paper describes the nature of the gliosis in the myelin deficient jimpy and relates these findings to other recent studies of experimentally induced demyelination in which gliosis is a prominent feature of the disorder. In jimpy males, an astroglial hypertrophy which consists of an increase in the number of cell processes can be demonstrated by both electron microscopy and immunocytochemistry using antibodies to glial fibrillary acidic protein. Increased glial fibrillary acidic protein staining in the white matter of jimpy males correlates with the normal time of myelination in different tracts. The immunostaining is not, however, restricted to white matter. Increased staining can be demonstrated in spinal cord grey matter when hardly any myelinated fibers are present, it is especially prominent around blood vessels of both white and grey matter, and is found in the corpus callosum and in the underlying subventricular zone shortly before or at the time myelination be...Continue Reading

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Citations

Apr 1, 1993·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·P E KnappR P Skoff
May 26, 1998·Brain Research. Brain Research Reviews·J M VelaB Castellano
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Sep 1, 1993·Journal of Neuroscience Research·S Amur-UmarjeeA T Campagnoni

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