Astroglial signalling in health and disease

Neuroscience Letters
Alexei Verkhratsky, Robert Zorec

Abstract

Astrocytes, the neural homeostatic cells, play a key role in the information processing in the central nervous system. They express multiple receptors which respond to a number of chemical messengers and get excited as evidenced by an increase in second messengers in short and delayed time domains. Astrocytes secrete numerous neuroactive agents and mount various homeostatic responses. These signal integrating functions are key factors of neuropathology (better termed astroneuropathology): they provide for neuroprotection through both homeostatic support and astroglial reactivity; failure in astroglial defensive or supporting capabilities facilitates evolution of neurological disorders.

Citations

Mar 29, 2020·Pflügers Archiv : European journal of physiology·Anatoly Shmygol
Jan 24, 2019·International Journal of Molecular Sciences·Celeste Caruso BavisottoClaudia Campanella
Oct 22, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·A Mark Evans
Apr 10, 2021·Frontiers in Cellular Neuroscience·Timo FischerChristian Lohr
Jan 25, 2022·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Maria Francesca PalmasAnna R Carta

❮ Previous
Next ❯

Related Concepts

Related Feeds

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

© 2022 Meta ULC. All rights reserved