Asymmetric allylic alkylation, an enabling methodology

The Journal of Organic Chemistry
Barry M Trost

Abstract

The diversity of mechanisms for enantiodiscrimination and of bond types that can be formed make Pd-catalyzed asymmetric allylic alkylation a powerful key step for simplification of synthetic strategy to complex molecular targets. Using a wide range of different classes of compounds including alkaloids, polyhydrofurans, nucleosides and carbanucleosides, cyclohexitols and cyclopentitols, chromanes, cyclopentanoids, amino acids, barbiturates, etc., novel synthetic strategies emerge that provide short efficient asymmetric syntheses.

References

Sep 21, 1989·Nature·M J Berridge, R F Irvine
Nov 1, 1986·Journal of Natural Products·G R PettitY Sagawa
Sep 1, 1985·Journal of Medicinal Chemistry·A M Koskinen, H Rapoport
Apr 1, 1968·The Journal of Antibiotics·T KusakaT Kishi
Jan 29, 2000·Journal of Natural Products·K D WellingtonP R Bergquist
Sep 27, 2001·Journal of the American Chemical Society·R TakeuchiN Shiga
Oct 25, 2001·The Journal of Organic Chemistry·Barry M. Trost, Lara S. Kallander
Feb 1, 1996·Chemical Reviews·Barry M. Trost, David L. Van Vranken
Aug 31, 2002·Angewandte Chemie·Barry M Trost, Weiping Tang
Dec 20, 2002·Angewandte Chemie·Barry M TrostZachary T Ball
Mar 13, 2003·Chemical Reviews·Deevi BasavaiahTummanapalli Satyanarayana
Jul 17, 2003·Journal of the American Chemical Society·Barry M Trost, Weiping Tang
Aug 2, 2003·Journal of the American Chemical Society·Barry M TrostJean-Philippe Surivet
Aug 14, 2003·Chemical Reviews·Barry M Trost, Matthew L Crawley
Sep 2, 2003·Angewandte Chemie·Barry M TrostJean-Philippe Surivet
Apr 9, 2004·Journal of the American Chemical Society·Barry M TrostGretchen M Schroeder
Apr 28, 2004·Chemistry : a European Journal·Barry M Trost, Matthew L Crawley

❮ Previous
Next ❯

Citations

Sep 30, 2010·Accounts of Chemical Research·John F Hartwig, Levi M Stanley
Jan 18, 2011·Chemical Reviews·Jimmie D WeaverJon A Tunge
Mar 3, 2005·Journal of the American Chemical Society·Stefan F Kirsch, Larry E Overman
Feb 24, 2006·Journal of the American Chemical Society·Barry M TrostKelvin Yong
Mar 23, 2006·Journal of the American Chemical Society·Barry M Trost, Aaron Aponick
May 11, 2006·Journal of the American Chemical Society·Barry M Trost, Jean Quancard
Nov 8, 2007·Journal of the American Chemical Society·Barry M Trost, Yong Zhang
Oct 15, 2010·Journal of the American Chemical Society·Jeffrey S CannonLarry E Overman
Oct 15, 2010·Journal of the American Chemical Society·Jeffrey S CannonHelen F Sneddon
Nov 4, 2011·Journal of the American Chemical Society·Jiadi ZhangPatrick J Walsh
Nov 25, 2011·Journal of the American Chemical Society·Philipp KoschkerBernhard Breit
Jan 31, 2008·Journal of the American Chemical Society·Pixu LiMadeleine M Joullié
Feb 20, 2010·Journal of the American Chemical Society·Baoguo ZhaoYian Shi
Jan 19, 2013·The Journal of Organic Chemistry·Igor DubovykAndrei K Yudin
Oct 18, 2013·The Journal of Organic Chemistry·Shao-Xiong ZhangZhi-Hui Shao
Sep 22, 2006·Organic Letters·Frederic MenardMark Lautens
Jul 23, 2011·Organic Letters·Vilius FranckevičiusRichard J K Taylor
Apr 26, 2013·Organic Letters·Supaporn NiyomchonNuno Maulide
May 12, 2005·Chemical Communications : Chem Comm·George W KabalkaZhongzhi Wu
Nov 1, 2007·Organic & Biomolecular Chemistry·Justin T MohrBrian M Stoltz
Oct 29, 2008·Chemical Communications : Chem Comm·Khalid B SelimKiyoshi Tomioka
Oct 18, 2011·Chemical Communications : Chem Comm·Huoji ChenHuanfeng Jiang
Sep 18, 2013·Proceedings of the National Academy of Sciences of the United States of America·Kenneth V LawsonPatrick G Harran
Feb 24, 2015·Chemical Science·Bi-Shun ZengKarl A Scheidt

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.