Asymmetric biodegradable microdevices for cell-borne drug delivery

ACS Applied Materials & Interfaces
Junfei XiaJingjiao Guan

Abstract

Use of live cells as carriers for drug-laden particulate structures possesses unique advantages for drug delivery. In this work, we report on the development of a novel type of particulate structures called microdevices for cell-borne drug delivery. The microdevices were fabricated by soft lithography with a disklike shape. Each microdevice was composed of a layer of biodegradable thermoplastic such as poly(lactic-co-glycolic acid). One face of the thermoplastic layer was covalently grafted with a cell-adhesive polyelectrolyte such as poly-l-lysine. This asymmetric structure allowed the microdevices to bind to live cells through bulk mixing without causing cell aggregation. Moreover, the cell-microdevice complexes were largely stable, and the viability and proliferation ability of the cells were not affected by the microdevices over a week. In addition, sustained release of a mock drug from the microdevices was demonstrated. This type of microdevice promises to be clinically useful for sustained intravascular drug delivery.

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Citations

Oct 30, 2016·Langmuir : the ACS Journal of Surfaces and Colloids·Junfei XiaJingjiao Guan
May 28, 2016·Experimental Biology and Medicine·James Pk Armstrong, Adam W Perriman
Jun 30, 2019·Advanced Materials·C Wyatt ShieldsSamir Mitragotri
Jun 5, 2020·Science Advances·C Wyatt ShieldsSamir Mitragotri
Feb 13, 2017·Journal of Controlled Release : Official Journal of the Controlled Release Society·Maxime Ayer, Harm-Anton Klok
Apr 16, 2021·ACS Applied Materials & Interfaces·Laura HaDong-Pyo Kim
Nov 7, 2018·Journal of the American Chemical Society·Jun YinXiangdong Gao
Jan 7, 2018·Langmuir : the ACS Journal of Surfaces and Colloids·Shuhuan HuRaymond H W Lam

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