Asymmetric Differences in the Gray Matter Volume and Functional Connections of the Amygdala Are Associated With Clinical Manifestations of Alzheimer's Disease

Frontiers in Neuroscience
Xingqi WuKai Wang

Abstract

Asymmetry is a subtle but pervasive aspect of the human brain, which may be altered in several neuropsychiatric conditions. Magnetic resonance imaging (MRI) studies have reported that cerebral structural asymmetries are altered in Alzheimer's disease (AD), but most of these studies were conducted at the region-of-interest level. At the functional level, there are few reports of resting-state functional asymmetries based on functional MRI. In this study, we investigated lateral differences in structural volumes and strengths of functional connectivity between individuals with AD and healthy controls (HCs) at the voxel level. Forty-eight patients with AD and 32 matched HCs were assessed. An analysis of voxel-based morphometry (VBM) of gray matter volume was performed at the whole-brain level to explore anatomical cerebral asymmetries in AD. We then performed a seed-to-whole-brain functional connectivity (FC) analysis to reveal FC asymmetries in AD. An asymmetry index (AI) was used to measure these changes, and the relationship between the structural and functional AIs and the clinical symptoms of AD was explored. A VBM analysis revealed a rightward and a leftward lateralization in the amygdala and the thalamus, respectively, in p...Continue Reading

References

Jan 1, 1991·Acta Neuropathologica·H Braak, E Braak
Feb 1, 1989·Archives of Neurology·D A LoewensteinR Duara
Jul 11, 1998·International Journal of Geriatric Psychiatry·C Brayne
Apr 5, 2003·Assessment·Michael N LopezSindy Oh
Aug 23, 2003·Stroke; a Journal of Cerebral Circulation·Jeremy D Schmahmann
Jun 15, 2004·NeuroImage·E LudersG Schlaug
Aug 9, 2005·NeuroImage·Matthias J MüllerAndreas Fellgiebel
Apr 7, 2007·Annals of the New York Academy of Sciences·Paul M ThompsonArthur W Toga
Apr 17, 2008·Human Brain Mapping·Jessica S DamoiseauxSerge A R B Rombouts
Jul 12, 2008·Annual Review of Psychology·David P Salmon, Mark W Bondi
Aug 2, 2008·Brain : a Journal of Neurology·Peita D BruenAnnalena Venneri
Jul 27, 2010·Radiology·Hong-Ying ZhangGao-Jun Teng
Mar 23, 2011·Journal of Alzheimer's Disease : JAD·Sabine DerflingerMark Mühlau
Sep 13, 2011·Neurobiology of Aging·Jong Hun KimDuk L Na
Oct 17, 2012·Brain Imaging and Behavior·Kwangsik NhoUNKNOWN Alzheimer’s Disease Neuroimaging Initiative--ADNI
Nov 13, 2012·Trends in Cognitive Sciences·Alan AnticevicJohn H Krystal
Feb 14, 2013·Frontiers in Plant Science·Khurram BashirNaoko K Nishizawa
May 28, 2013·Brain Connectivity·Ziad S SaadRobert W Cox
Jul 23, 2013·Frontiers in Human Neuroscience·Stephen J GottsAlex Martin
Jan 17, 2015·Nature·Patricia H Janak, Kay M Tye
May 6, 2015·Annual Review of Neuroscience·Marcus E Raichle
Jan 27, 2016·Ageing Research Reviews·Hiroshi Matsuda
Dec 4, 2016·Brain : a Journal of Neurology·Christian WachingerUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Mar 1, 2017·Neurology. Clinical Practice·Matthew R WoodwardKinga Szigeti
Jul 20, 2017·NeuroImage·Felipe Gutierrez-BarraganUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Sep 1, 2017·Human Brain Mapping·Lora MinkovaStefan Klöppel
Mar 13, 2018·NeuroImage. Clinical·Lora MinkovaUNKNOWN TRACK-HD Investigators
Apr 5, 2018·Journal of Alzheimer's Disease : JAD·Katerina A TetzloffJennifer L Whitwell
Aug 14, 2018·NeuroImage. Clinical·Christopher M WeiseUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Nov 2, 2019·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Audrey LowJohn T O'Brien

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Software Mentioned

DARTEL
Statistical Parametric Mapping SPM
Statistical non - Parametric Mapping
Statistical Package for the Social Sciences
VBM8
SPM

Related Concepts

Related Feeds

Alzheimer's Disease: Neuroimaging

Neuroimaging can help identify pathological hallmarks of Alzheimer's disease (AD). Here is the latest research on neuroimaging modalities, including magnetic resonance imaging and positron emission tomography, in AD.

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.