Asymmetric Dimethyl-L-Arginine is a Biomarker for Disease Stage and Follow-Up of Pulmonary Hypertension Associated with Congenital Heart Disease

Pediatric Cardiology
Zhen-fei FangSheng-hua Zhou

Abstract

This study investigated the clinical value of plasma asymmetrical dimethyl-L-arginine (ADMA) level in the diagnosis, staging, and treatment response in congenital heart disease (CHD) patients with pulmonary arterial hypertension (PAH). This was a single-center prospective observational study in 80 CHD patients. Plasma ADMA levels were measured by enzyme-linked immunosorbent assay. Plasma ADMA levels were significantly increased in CHD patients with PAH compared with CHD patients without PAH (P < 0.01) and healthy controls (P < 0.001). In CHD patients with severe PAH, plasma ADMA levels were significantly higher in patients with Eisenmenger's syndrome (ES) than in patients exhibiting low pulmonary vascular resistance (P < 0.001). The plasma ADMA levels significantly correlated with pulmonary arterial pressure (P < 0.001) and pulmonary vascular resistance (P < 0.001) in patients with CHD. Severe PAH was identified by plasma ADMA with a cutoff value of 0.485 μmol/L (P < 0.001) with a specificity of 82.8 % and a sensitivity of 90 %. ES was identified by plasma ADMA with a cutoff value of 0.85 μmol/L (P < 0.05) with a specificity of 85.2 % and a sensitivity of 64.3 %. ADMA levels were significantly decreased after sildenafil therapy...Continue Reading

References

May 30, 1991·The New England Journal of Medicine·A T Dinh-XuanJ Wallwork
Jan 1, 1970·Cardiovascular Research·C G LaFarge, O S Miettinen
Dec 16, 1998·Annals of Internal Medicine·W VongpatanasinR A Lange
Apr 30, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Jan T KielsteinMarius M Hoeper
Sep 18, 2007·American Journal of Respiratory and Critical Care Medicine·Nika Skoro-SajerIrene M Lang
Aug 2, 2008·The European Respiratory Journal·G WarwickD H Yates
Sep 30, 2010·Revista española de cardiología·Maurice Beghetti, Cecile Tissot
Dec 4, 2012·European Respiratory Review : an Official Journal of the European Respiratory Society·Michele D'Alto, Vaikom S Mahadevan
Jul 25, 2013·Chest·Vasile ForisHorst Olschewski
Nov 26, 2013·Clinics in Chest Medicine·Usha Krishnan, Erika B Rosenzweig

❮ Previous
Next ❯

Citations

Sep 27, 2018·International Angiology : a Journal of the International Union of Angiology·Anna M WieczórDanuta Rość
Jan 10, 2019·Antioxidants & Redox Signaling·Evgeny A ZemskovStephen M Black
Apr 22, 2020·Pulmonary Circulation·Juliane HannemannRainer Böger
May 23, 2020·Current Medicinal Chemistry·Zsófia LázárAndras Bikov

❮ Previous
Next ❯

Related Concepts

Related Feeds

Biomarkers for Cardiovascular Risk Assessment

Sensitive and accurate biomarkers used in cardiovascular risk prediction can potentially be used to manage the risk of cardiovascular disease. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here.

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.