Asymmetric dimethylarginine as a mediator of vascular dysfunction in cirrhosis

World Journal of Gastroenterology : WJG
Paloma LluchPascual Medina

Abstract

Cirrhosis is associated with marked abnormalities in the circulatory function that involve a reduction in systemic vascular resistance. An important cause of this vasodilatation is the increased production or activity of nitric oxide (NO) in the splanchnic circulation. During portal hypertension and cirrhosis an increased endothelial NO synthase (eNOS) activity is demonstrated in splanchnic vessels. In contrast, the activity of eNOS in the cirrhotic liver is decreased, which suggests a different regulation of eNOS in the liver and in the splanchnic vessels. Asymmetric dimethylarginine (ADMA) is an endogenous NO inhibitor and higher plasma levels of ADMA are related to increased cardiovascular risk in both the general population and among patients with cirrhosis. It has been demonstrated that the liver is a key player in the metabolism of ADMA. This observation was further supported by investigations in human patients, showing a close correlation between ADMA plasma levels and the degree of hepatic dysfunction. ADMA is degraded to citrulline and dimethylamine by dimethylarginine dimethylaminohydrolases (DDAHs). DDAHs are expressed as type 1 and 2 isoforms and are widely distributed in various organs and tissues, including the li...Continue Reading

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Citations

Jun 7, 2016·Prostaglandins & Other Lipid Mediators·Sabrina KrautbauerChrista Buechler
Aug 16, 2016·The Science of the Total Environment·Lucía G Pruneda-AlvarezIván N Pérez-Maldonado
Nov 4, 2017·International Journal of Molecular Sciences·Krzysztof MilewskiMagdalena Zielińska
May 26, 2018·Annals of Laboratory Medicine·Faruk KarakeciliBaris Gulhan
Dec 22, 2017·Archives of Environmental Contamination and Toxicology·Ángeles C Ochoa-MartínezIván N Pérez-Maldonado
Dec 6, 2017·Molecular Medicine Reports·Zhenguo LiuXuegong Fan
Jan 14, 2017·World Journal of Gastroenterology : WJG·Gloria SegarraPascual Medina

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