Asymmetric dimethylarginine in hemodialysis, hemodiafiltration, and peritoneal dialysis

Artificial Organs
Jaromír EiseltSylvie Opatrná

Abstract

Asymmetric dimethylarginine (ADMA) is a mediator of endothelial dysfunction. Production and elimination of ADMA may be affected by the type of renal replacement therapy used and oxidative stress. Plasma ADMA, advanced glycation end products (AGE), and homocysteine were assessed in 59 subjects: 20 hemodialysis (HD) patients, 19 patients undergoing peritoneal dialysis (PD), and 20 controls. Results were compared between the groups. The effect of 8 weeks of HD and high-volume predilution hemodiafiltration (HDF) was compared in a randomized study. HD patients showed higher ADMA (1.20 [0.90-1.39 micromol/L]) compared to controls (0.89 [0.77-0.98], P < 0.01), while ADMA in PD did not differ from controls (0.96 [0.88-1.28]). AGE and homocysteine were highest in HD, lower in PD (P < 0.01 vs. HD), and lowest in controls (P < 0.001 vs. HD and PD). PD patients had higher residual renal function than HD (P < 0.01). The decrease in ADMA at the end of HD (from 1.25 [0.97-1.33] to 0.66 [0.57-0.73], P < 0.001) was comparable to that of HDF. Switching from HD to HDF led to a decrease in predialysis homocysteine level in 8 weeks (P < 0.05), while ADMA and AGE did not change. Increased ADMA levels in patients undergoing HD, as compared to PD, may...Continue Reading

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Citations

Apr 18, 2013·International Urology and Nephrology·Aleksandra M IgnjatovićDragan Bogdanović
Oct 2, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Paweena SusantitaphongBertrand L Jaber
Mar 21, 2012·Nephrology·Toshihide NaganumaTatsuya Nakatani
Mar 16, 2011·Artificial Organs·Paul S Malchesky
May 2, 2014·Seminars in Nephrology·Eva SchepersJan T Kielstein
Jun 25, 2014·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Kathleen J ClaesPieter Evenepoel
May 21, 2014·Nephrology·Chiz-Tzung ChangChiu-Ching Huang
Feb 18, 2011·Mass Spectrometry Reviews·Toshimitsu Niwa
Nov 25, 2011·Hemodialysis International·Stéphanie BadiouJean-Paul Cristol

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