Asymmetric dimethylarginine is closely associated with the development and progression of nephropathy in patients with type 2 diabetes

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Ko HanaiYasuhiko Iwamoto

Abstract

Nitric oxide (NO) is thought to play an important role in the pathogenesis of diabetic nephropathy. We conducted a prospective, observational cohort study to explore the relationship between plasma levels of asymmetric dimethylarginine (ADMA), an endogenous inhibitor of NO synthase, and the development and progression of nephropathy in patients with type 2 diabetes. This was a hospital-based observational cohort study in Japanese type 2 diabetic patients with normoalbuminuria [urinary albumin-to-creatinine ratio (ACR) <30 mg/g creatinine] or microalbuminuria (30 < or = ACR <300 mg/g creatinine). The primary endpoint was the development or progression of diabetic nephropathy, based on transition from any given stage to a more advanced stage of albuminuria. We studied 225 diabetic patients, 81 women and 144 men, with a mean (+/-SD) age of 64 +/- 10 years. The majority (183) of patients were normoalbuminuric, with the remainder microalbuminuric (42). During the median follow-up period of 5.2 years, 27 normoalbuminuric and 10 microalbuminuric patients reached the primary endpoint. When patients were separated according to the median ADMA level (0.46 mumol/l), patients with higher ADMA levels had a greater incidence of reaching the ...Continue Reading

References

Jan 5, 2002·Diabetes Research and Clinical Practice·Takeshi KuzuyaUNKNOWN Committee of the Japan Diabetes Society on the diagnostic criteria of diabetes mellitus
Sep 13, 2002·Circulation Journal : Official Journal of the Japanese Circulation Society·Akira ItoAkira Takeshita
Sep 30, 2003·Journal of the American Society of Nephrology : JASN·Julie LinAjay K Singh
Dec 25, 2003·Diabetes Care·Mark E MolitchUNKNOWN American Diabetes Association
Jul 15, 2004·Seminars in Nephrology·Sharma S Prabhakar
Jun 3, 2005·Journal of the American Society of Nephrology : JASN·Danilo FliserEberhard Ritz
Aug 2, 2005·Journal of the American College of Cardiology·Francesco PerticoneCarmine Zoccali
Aug 23, 2005·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Jan T Kielstein, Carmine Zoccali
Dec 1, 2005·Current Diabetes Reports·Sharma S Prabhakar
Aug 16, 2006·Annals of Internal Medicine·Andrew S LeveyUNKNOWN Chronic Kidney Disease Epidemiology Collaboration
Jan 5, 2007·Journal of the American Society of Nephrology : JASN·Takahiko NakagawaByron Croker
Apr 26, 2007·Diabetes Care·Katarzyna KrzyzanowskaGuntram Schernthaner
Nov 27, 2007·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Enyu ImaiSeiichi Matsuo
Feb 2, 2008·Arteriosclerosis, Thrombosis, and Vascular Biology·Karsten SydowJohn P Cooke

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Citations

Jul 9, 2010·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Ryotaro BouchiYasuhiko Iwamoto
Nov 26, 2009·Nature Reviews. Nephrology·Florian Kronenberg
Sep 29, 2012·Nephrology·Vasileios RaptisDimitrios Grekas
Dec 4, 2012·International Journal of Molecular Sciences·Angela SciacquaFrancesco Perticone
Jun 2, 2011·Cardiology Research and Practice·Katarzyna KrzyzanowskaGuntram Schernthaner
Jan 6, 2016·The Journal of Pharmacology and Experimental Therapeutics·Carine M Boustany-KariSteven S Pullen
Jan 5, 2011·International Journal of Nephrology·Akihiko SaitoHiroyoshi Sato
Jan 28, 2014·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Richard J MacisaacGeorge Jerums
Jun 24, 2011·Kidney International·Robert G FassettWendy E Hoy
Nov 4, 2010·Advances in Chronic Kidney Disease·Prasad Devarajan
Aug 18, 2009·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Tom TeerlinkChristopher S Wilcox
Jan 16, 2016·Journal of Diabetes Research·Li Lai, Yohannes T Ghebremariam
Jul 4, 2015·Clinical Pharmacokinetics·Frederique RodieuxMarc Pfister
Sep 15, 2011·Diabetic Medicine : a Journal of the British Diabetic Association·M E HellemonsM Rudnicki
May 21, 2014·Journal of Diabetes Investigation·Ko HanaiYasuko Uchigata
Sep 6, 2011·Diabetes Research and Clinical Practice·Ayten CanNevin Dinccag
Jun 17, 2015·Amino Acids·Anne-Roos S FrenayHarry van Goor
May 15, 2012·Diabetes Research and Clinical Practice·Hyun-Ae SeoKeun-Gyu Park
Jun 4, 2011·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Sho-Ichi Yamagishi, Takanori Matsui
Apr 24, 2012·Journal of Diabetes and Its Complications·Rhys D FogartyKathryn P Burdon
Dec 29, 2016·Endocrinology and Metabolism·Masami Tanaka, Hiroshi Itoh
Apr 13, 2010·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Maike AnderssohnRainer H Böger
Jun 17, 2009·Journal of Cardiovascular Pharmacology·Pitchai BalakumarMadhu B Anand-Srivastava
Aug 21, 2010·Diabetic Medicine : a Journal of the British Diabetic Association·M OhtaY Iwamoto
Feb 24, 2018·Journal of the American Society of Nephrology : JASN·Florian Kronenberg
Aug 26, 2014·Journal of the American Society of Nephrology : JASN·Giovanni TripepiCarmine Zoccali
Oct 9, 2019·Toxins·Laetitia Dou, Noémie Jourde-Chiche
Oct 21, 2016·Journal of Cardiovascular Pharmacology·Mei-Rong DuJun-Lin Jiang
Sep 23, 2020·Experimental Biology and Medicine·Radosław WieczórDanuta Rość
Aug 30, 2018·Experimental & Molecular Medicine·Joo-Hee ChoiJong-Hwan Park
Jun 15, 2012·Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine·Seiji UedaSeiya Okuda

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