PMID: 12782276Jun 5, 2003Paper

Asymmetric limb malformations in a new transgene insertional mutant, footless

Mechanisms of Development
Sheila M BellWilliam J Scott

Abstract

Six to eight copies of a transgene integrated into mouse chromosome 15 resulting in a new transgene insertional mutant, Footless, presenting with malformations of the limbs, kidney, and soft palate. Homozygotes possess a unique asymmetric pattern of limb truncations. Posterior structures from the autopod and zeugopod of the hindlimbs are missing with left usually more severely affected than right. In contrast, anterior structures are missing from the right forelimbs. The left forelimb is usually normal except for the absence of the distal telephalanges and nails. These structures are absent on all formed digits. In situ hybridization assays examined the expression of Shh, dHand, Msx2, Fgf8, En1, and Lmx1b in mutant limb buds and indicated normal establishment of the anterior/posterior and dorsal/ventral axes of the developing limbs. However, dysmorphology of the apical ectodermal ridge was observed in the mutant limb buds.

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Citations

Apr 11, 2008·Molecular Biology of the Cell·Kyung-Ah KimArie Abo
Feb 15, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yuan ChengAaron J W Hsueh
Oct 11, 2011·Cellular Signalling·Jeong Kyo Yoon, Jin-Seon Lee
Nov 26, 2008·Seminars in Cell & Developmental Biology·Patrick Allard, Clifford J Tabin
Nov 4, 2015·Frontiers in Genetics·Emanuele PelosiDavid Schlessinger
Feb 12, 2011·Journal of Morphology·Christine PomikalJohannes Streicher
Jul 2, 2014·Matrix Biology : Journal of the International Society for Matrix Biology·M Noelle Knight, Kurt D Hankenson
Nov 17, 2009·Developmental Biology·Ana TalamilloMaria A Ros
Dec 20, 2016·PLoS Genetics·Fatima A SulaimanMalcolm P O Logan
Sep 10, 2014·Endocrine Reviews·Aaron J W HsuehBart C J M Fauser
Apr 29, 2020·Cell Death and Differentiation·Marie-Cécile De CianMarie-Christine Chaboissier
Aug 23, 2018·Bone Research·M Noelle KnightKurt D Hankenson
Nov 13, 2020·Genetics, Selection, Evolution : GSE·Doreen BeckerChrista Kühn
Feb 8, 2008·Development·Sheila M BellJeffrey A Whitsett
May 7, 2021·American Journal of Medical Genetics. Part a·Alison M ElliottJane A Evans

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