Asymmetric membrane in membrane capsules: a means for achieving delayed and osmotic flow of cefadroxil

European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V
Anil K PhilipPragati Shakya

Abstract

In the present study, both disintegrating and non-disintegrating polymeric capsular system in achieving delayed as well as improved osmotic flow for the model drug cefadroxil was developed. Asymmetric membrane in membrane capsule (AMMC) was prepared on a glass mold pin via phase inversion process in two steps. Step 1 included formation of a non-disintegrating, asymmetric membrane capsule (AMC) and step 2 involved formation of a pH sensitive, disintegrating, asymmetric membrane (AM) formed over the non-disintegrating membrane. The effects of different formulation variables were studied namely, level of osmogen, membrane thickness, and level of pore former. Effects of varying osmotic pressure, agitational intensity and intentional defect in the inner membrane on drug release were also studied. Membrane characterization by scanning electron microscopy showed dense regions with less pores on the outer surface of the disintegrating membrane and porous regions on the inner surface of the non-disintegrating asymmetric membrane. In vitro release studies for all the prepared formulations were done (n=6). The drug release was independent of pH, agitational intensity and intentional defect on the membrane but dependent on the osmotic pres...Continue Reading

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Citations

Apr 1, 2010·Oman Medical Journal·Anil K Philip, Betty Philip
Oct 12, 2013·Drug Development and Industrial Pharmacy·Yan YangWei-san Pan
Dec 4, 2013·Drug Development and Industrial Pharmacy·Wenji ZhangWeisan Pan
Sep 30, 2015·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·G PrudhvirajK Gowthamarajan
Apr 2, 2015·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Sachin Kumar SinghYogyata Vaidya
Jan 21, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Niranjan Goud KotlaAshwini Shivapooja
May 1, 2010·Pharmaceutical Development and Technology·Xiongkai ChengGuangxi Zhai
Feb 11, 2020·Water Science and Technology : a Journal of the International Association on Water Pollution Research·Xiaoqiang LiYonggui Li
May 21, 2010·Pharmaceutical Development and Technology·Anil K Philip, Betty Philip
Aug 22, 2021·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Betty Annie SamuelAnil K Philip

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