Asymmetric motion distribution between components of a mobile-core lumbar disc prosthesis: an explanation of unequal wear distribution in explanted CHARITÉ polyethylene cores

The Journal of Bone and Joint Surgery. American Volume
Avinash G PatwardhanLeonard I Voronov

Abstract

The biconvex mobile core of the CHARITÉ lumbar disc prosthesis forms two joints (spherical bearings) with the metal end plates. We quantified the intra-prosthesis motion to test the hypothesis that the total prosthesis motion would not be equally distributed between the two bearings of implanted CHARITÉ discs, which might explain the unequal wear distribution reported in explanted cores. The hypothesis was tested by studying the flexion-extension motion responses of (1) twenty-six monosegmental CHARITÉ III discs implanted in nineteen human cadaveric lumbar spines, and (2) twenty-one CHARITÉ III discs (fifteen monosegmental, six bisegmental) implanted in eighteen patients in other published clinical studies. Intra-prosthesis motions were quantified with use of a radiographic image analysis technique. Eighty-eight percent of the CHARITÉ discs implanted in cadaveric specimens exhibited larger motion at the superior bearing, with 54% demonstrating more than twice as much motion at the superior bearing as at the inferior bearing. The ratio of motion at the superior bearing to motion at the inferior bearing averaged 2.68 ± 1.84, which was significantly larger than 1.0 (p < 0.001). Ninety percent of prostheses implanted in patients sh...Continue Reading

References

Apr 25, 2000·International Orthopaedics·A H Sott, D J Harrison
Apr 23, 2003·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Avinash G PatwardhanOdysseas Paxinos
Aug 7, 2003·Journal of Spinal Disorders & Techniques·Paul C McAfeeBryan W Cunningham
Sep 5, 2003·The Journal of Bone and Joint Surgery. American Volume·Avinash G PatwardhanFrank M Phillips
Nov 1, 2003·The Spine Journal : Official Journal of the North American Spine Society·Scott L BlumenthalRobert Winter
May 3, 2005·The Spine Journal : Official Journal of the North American Spine Society·Steven M KurtzMarta L Villarraga
Jun 14, 2005·The Orthopedic Clinics of North America·John J Regan
Jul 16, 2005·Journal of Spinal Disorders & Techniques·Jean-Philippe LemaireFrançois Lavaste
Jul 19, 2005·Journal of Biomechanics·Kristin ZhaoKai-Nan An
Oct 22, 2005·Clinical Orthopaedics and Related Research·Timothy M Wright
Oct 29, 2005·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Michael PutzierFrank Kandziora
Nov 18, 2005·The Spine Journal : Official Journal of the North American Spine Society·Patrick O'LearyAvinash G Patwardhan
Dec 7, 2005·Clinical Orthopaedics and Related Research·John M Cuckler
May 3, 2006·The Spine Journal : Official Journal of the North American Spine Society·Marc-Antoine RousseauJeffery C Lotz
Jan 2, 2007·Clinical Biomechanics·Manohar M Panjabi
Jan 2, 2007·The Spine Journal : Official Journal of the North American Spine Society·Steven M KurtzMarta L Villarraga
Jan 4, 2007·The Journal of Bone and Joint Surgery. American Volume·P Justin TortolaniKaren A Adams
Apr 24, 2007·Spine·Manohar PanjabiHassan Serhan
Oct 12, 2007·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Ilona M PuntAndré van Ooij
Apr 29, 2008·The Spine Journal : Official Journal of the North American Spine Society·Frank M PhillipsAvinash G Patwardhan

❮ Previous
Next ❯

Citations

Apr 29, 2014·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Matthew F GornetJohn A Hipp
Jan 10, 2018·Clinical Spine Surgery : a Spine Publication·Timothy T RobertsEdward C Benzel
Nov 8, 2020·The Spine Journal : Official Journal of the North American Spine Society·Avinash G PatwardhanMuturi G Muriuki

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.