PMID: 7022130Jan 1, 1981Paper

Asymmetric repair of bacteriophage T7 heteroduplex DNA

Molecular & General Genetics : MGG
J BauerR Knippers

Abstract

Heteroduplex DNA molecules were prepared in vitro using one strand of DNA carrying a point mutation and one strand of the corresponding wild-type DNA. The heteroduplex DNA was transfected into competent bacteria and the progeny genotypes in the resulting infective centers were determined. From the results we conclude that about 80% of all transfected DNA molecules are repaired before DNA replication starts. This fraction of repaired DNA is independent of the location of the mismatched nucleotide pair. However, mismatch correction occurs preferentially on the H strand of the heteroduplex DNA. The repair does not depend on a known phage coded function but requires the active bacterial genes mutU, mutH, mutS and probably mutL.

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Citations

Jan 1, 1983·Molecular & General Genetics : MGG·K Bebenek, C Janion
Jan 1, 1982·Molecular & General Genetics : MGG·E Sledziewska-Gójska, C Janion
Jan 1, 1984·Journal of Molecular Evolution·M McClelland
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Aug 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·A L LuP Modrich
Mar 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·R S LahueP Modrich
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May 1, 1987·Molecular and Cellular Biology·D AyaresR Kucherlapati
Sep 1, 1990·Mutation Research·M GrilleyP Modrich
Jun 1, 1986·Microbiological Reviews·J P Claverys, S A Lacks

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