Asymmetric requirement of surface epithelial β-catenin during the upper and lower jaw development.

Developmental Dynamics : an Official Publication of the American Association of Anatomists
Ye SunXue Li

Abstract

Intercellular communication between epithelial and mesenchymal cells is central to mammalian craniofacial development. β-catenin is the gateway of canonical Wnt signaling, one of the major evolutionarily conserved cell-cell communication pathways in metazoa. In this study, we report an unexpected stage- and tissue-specific function of β-catenin during mammalian jaw development. Using a unique mouse genetic tool, we have discovered that epithelial β-catenin is essential for lower jaw formation, while attenuation of β-catenin is required for proper upper jaw development. Changes in β-catenin in vivo alter major epithelial Fgf8, Bmp4, Shh, and Edn1 signals, resulting in partial transcriptional reprogramming of the neural crest-derived mesenchyme, the primary source of jawbones. The Wnt/β-catenin signal coordinates expression of multiple epithelial signals and has stage-specific asymmetric functions during mammalian upper and lower jaw development. In addition, these findings suggest that evolutionary changes of the canonical Wnt/β-catenin signaling pathway may lead to innovation of jaws.

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Citations

Jan 1, 2014·Journal of Bioscience and Bioengineering·Masayoshi KawakamiAkio Wanaka
Jan 11, 2017·Molecular and Cellular Biology·Feixue LiZunyi Zhang
Oct 5, 2018·PLoS Genetics·Zhao SunBrad A Amendt
Oct 12, 2013·Journal of Anatomy·Donald L Swiderski, Miriam L Zelditch
Aug 5, 2017·Scientific Reports·Walid D FakhouriBrian C Schutte
Jul 25, 2021·International Journal of Molecular Sciences·Jaroslav FabikOndrej Machon

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Methods Mentioned

BETA
transgenic
dissection
genetic modifications
dissecting

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