Asymmetric Suzuki-Miyaura cross-coupling for the synthesis of chiral biaryl compounds as potential monophosphine ligands

Chemistry : a European Journal
Yan-Na Ma, Shang-Dong Yang

Abstract

Efficient asymmetric Suzuki-Miyaura coupling reactions have been employed for the first time to synthesize chiral biaryl compounds with phosphinate groups as chiral auxiliaries. A series of functionalized chiral biaryls are thereby synthesized in excellent yields and good diastereoselectivities (up to >95:5 d.r.) and axially chiral monophosphorus ligands are obtained through further functionalizations.

References

Jul 30, 1999·Angewandte Chemie·K C NicolaouN Winssinger
Dec 26, 2001·Chemical Reviews·P W van LeeuwenP Dierkes
May 9, 2002·Chemical Reviews·Jwanro HassanMarc Lemaire
Jun 5, 2003·Journal of the American Chemical Society·Carol A MulrooneyMarisa C Kozlowski
Aug 29, 2003·Organic Letters·Pierre-Emmanuel Broutin, Françoise Colobert
Nov 5, 2008·Journal of the American Chemical Society·Antonio BermejoJosé M Lassaletta
Apr 14, 2009·Journal of the American Chemical Society·Hiromichi Egami, Tsutomu Katsuki
Apr 22, 2009·Chemical Reviews·Gráinne C Hargaden, Patrick J Guiry
Oct 23, 2009·Chemical Society Reviews·Marisa C KozlowskiElizabeth C Linton
Apr 16, 2011·Chemistry : a European Journal·Jie HuShang-Dong Yang
Aug 2, 2011·Chemistry : a European Journal·Meng SunShang-Dong Yang
Apr 17, 2012·Organic & Biomolecular Chemistry·Timo LeermannFrançoise Colobert
Apr 19, 2012·The Journal of Organic Chemistry·Abel RosJosé M Lassaletta
Nov 9, 2012·Organic & Biomolecular Chemistry·Hong-Yu ZhangShang-Dong Yang
Oct 9, 2013·Organic Letters·Hong-Li WangShang-Dong Yang
Oct 24, 2013·Journal of the American Chemical Society·Guangqing XuWenjun Tang
Nov 12, 2013·Organic Letters·Hong-Yu ZhangShang-Dong Yang
Mar 25, 2014·Chemical Communications : Chem Comm·Heng ZhangShang-Dong Yang

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Citations

Feb 7, 2017·The Journal of Organic Chemistry·Shuang LiuZhiwei Miao
May 10, 2017·Accounts of Chemical Research·Yan-Na MaShang-Dong Yang
Oct 7, 2016·Dalton Transactions : an International Journal of Inorganic Chemistry·James T FlemingLee J Higham
Aug 2, 2016·Chemical Society Reviews·Mathieu DutartreSylvain Jugé
Jul 21, 2016·Organic & Biomolecular Chemistry·Olivier Berger, Jean-Luc Montchamp
Mar 19, 2016·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Yan-Na Ma, Shang-Dong Yang
Aug 14, 2019·The Journal of Organic Chemistry·Yan-Na MaXuenian Chen
Apr 9, 2020·Journal of the American Chemical Society·Shengyi YanShao-Hua Xiang

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