Asymmetric synthesis of 1,2-fluorohydrin: iridium catalyzed hydrogenation of fluorinated allylic alcohol.

Chemical Science
Sudipta PonraPher G Andersson

Abstract

We have developed a simple protocol for the preparation of 1,2-fluorohydrin by asymmetric hydrogenation of fluorinated allylic alcohols using an efficient azabicyclo thiazole-phosphine iridium complex. The iridium-catalyzed asymmetric synthesis of chiral 1,2-fluorohydrin molecules was carried out at ambient temperature with operational simplicity, and scalability. This method was compatible with various aromatic, aliphatic, and heterocyclic fluorinated compounds as well as a variety of polyfluorinated compounds, providing the corresponding products in excellent yields and enantioselectivities.

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Sep 29, 2018·Journal of the American Chemical Society·Sudipta PonraPher G Andersson
Apr 18, 2019·Angewandte Chemie·Sudipta PonraPher G Andersson

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Citations

Jun 2, 2021·Chemical Society Reviews·T CharvillatT Besset

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Methods Mentioned

BETA
X-ray

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