Asymmetric synthesis of allylic amines via hydroamination of allenes with benzophenone imine

Chemical Science
Kun XuBernhard Breit

Abstract

Rhodium-catalyzed highly regio- and enantioselective hydroamination of allenes is reported. Exclusive branched selectivities and excellent enantioselectivities were achieved applying a rhodium(i)/Josiphos catalyst. This method permits the practical synthesis of valuable α-chiral allylic amines using benzophenone imine as ammonia carrier.

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Citations

Jul 10, 2019·Chemical Society Reviews·Carmen NájeraMiguel Yus
Sep 13, 2019·Chembiochem : a European Journal of Chemical Biology·Jesús Albarrán-VeloVicente Gotor-Fernández
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Dec 10, 2016·Chemical Communications : Chem Comm·Marco BortoluzziStefano Zacchini
Jul 28, 2016·Accounts of Chemical Research·Philipp Koschker, Bernhard Breit
Aug 23, 2019·Journal of the American Chemical Society·Gaël TranClément Mazet
Dec 20, 2019·Organic Letters·Yuta KondoTakashi Ohshima
Nov 18, 2017·The Journal of Organic Chemistry·Elisabet SelvaDavid Guijarro
Feb 28, 2017·Journal of the American Chemical Society·Han ZhouSanzhong Luo

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Methods Mentioned

BETA
NMR
acylation

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