Asymmetric synthesis of CF3 -containing tetrahydroquinoline via a thiourea-catalyzed cascade reaction

Organic & Biomolecular Chemistry
Yuanyuan ZhuRui Wang

Abstract

An organocatalytic asymmetric method for the synthesis of 2-CF3 tetrahydroquinoline has been achieved. The cascade reaction of 2-aminochalcones with β-CF3 nitroalkenes afforded the products bearing three contiguous stereogenic centers in good yields with excellent diastereoselectivities and enantioselectivities.

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Citations

Jul 19, 2018·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Xiang LiBo Han
Jun 1, 2021·Chemistry : a European Journal·Mohammed Anif PashaDhevalapally B Ramachary
Jul 27, 2021·ACS Catalysis·Chibueze I Onyeagusi, Steven J Malcolmson
Apr 10, 2019·Chemical Reviews·Isravel MuthukrishnanJ Carlos Menéndez
Aug 28, 2021·The Journal of Organic Chemistry·Chandrakanta ParidaSubhas Chandra Pan

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