Asymmetric Synthesis of Furo[3,4-b]indoles by Catalytic [3+2] Cycloaddition of Indoles with Epoxides

Chemistry : a European Journal
Weiliang ChenXiaoming Feng

Abstract

A highly efficient N,N'-dioxide-Ni(II) catalyst system for the catalytic [3+2] cycloaddition of indoles with epoxides through C-C cleavage of oxiranes was accomplished under mild conditions. It provided a promising approach for chiral furo[3,4-b]indoles in up to 98% yield with up to 91% enantiomeric excess (ee) and >95:5 diastereomeric ratio (d.r.).

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Citations

Apr 20, 2016·Journal of the American Chemical Society·Lin HuangShu-Li You
Apr 13, 2017·Organic & Biomolecular Chemistry·Jing-Biao Chen, Yi-Xia Jia
Feb 10, 2018·Chemistry, an Asian Journal·Paridhi Saxena, Manmohan Kapur
Oct 14, 2017·Chemical Communications : Chem Comm·Shulin GeXiaoming Feng
Feb 25, 2021·Chemical Communications : Chem Comm·Qingfa TanXiaoming Feng
May 7, 2021·Chemical Communications : Chem Comm·Ji-Wei SangHai-Ming Guo
Oct 3, 2017·Accounts of Chemical Research·Xiaohua LiuXiaoming Feng

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