Asymmetric vinylogous Mukaiyama aldol reaction of isatins under bifunctional organocatalysis: enantioselective synthesis of substituted 3-hydroxy-2-oxindoles

Chemical Communications : Chem Comm
Víctor Laina-MartínJosé Alemán

Abstract

A highly enantioselective organocatalytic vinylogous Mukaiyama aldol reaction of silyloxy dienes and isatins under bifunctional organocatalysis is presented. Substituted 3-hydroxy-2-oxindoles are synthesised in good yields and enantioselectivities. These synthetic intermediates are used for the construction of more complex molecules with biological properties such as the formal synthesis of a CB2 agonist presented.

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Citations

Apr 24, 2018·Chemistry : a European Journal·María FríasJosé Alemán
May 16, 2019·Chemical Communications : Chem Comm·Jindong LiZhiyong Wang
Aug 25, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Martin Cordes, Markus Kalesse
Aug 31, 2018·Journal of the American Chemical Society·Hai-Jun Zhang, Liang Yin

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