Abstract
In order to develop novel anti-cancer agents, a series of asymmetrical 2,6-bis (benzylidene)cyclohexanone derivatives containing nitrobenzylidene moiety were synthesized and their cytotoxic activity were determined in vitro against MDA-MB 231, MCF-7 and SK-N-MC cell lines using MTT assay. Among the tested compounds, the highest activity against MDA-MB 231 cells was achieved by 2-(3-bromo-5-methoxy-4-propoxybenzylidene)-6-(2-nitrobenzylidene)cyclohexanone (compound 5d). Whereas, compound 5j (the 3-nitro analog of compound 5d) was the most potent compound against MCF-7 and SK-N-MC cell lines. The results indicated that the cytotoxic activity profile against different tumor cells can be optimized by desired 4-alkoxy-3-bromo-5-methoxybenzylidene scaffold.
References
Sep 14, 1994·Journal of Immunological Methods·A A van de LoosdrechtM M Langenhuijsen
Jun 1, 1997·Anti-cancer Drugs·K MehtaB B Aggarwal
Jan 27, 2000·Cell·D Hanahan, R A Weinberg
Nov 24, 2007·Chemical Biology & Drug Design·Najmeh EdrakiMehdi Khoshneviszade
Apr 8, 2009·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·R Appiah-OpongN P E Vermeulen
Citations
May 3, 2013·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Mohsen VosooghiAlireza Foroumadi
Jun 3, 2014·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Eskandar AlipourAlireza Foroumadi
Jan 1, 2014·Journal of Molecular Graphics & Modelling·Karen L LangEduardo B de Melo
Jan 24, 2015·Molecular Diversity·Tahmineh AkbarzadehAlireza Foroumadi
Jun 20, 2016·European Journal of Medicinal Chemistry·Hassan Mirzaei, Saeed Emami
Aug 20, 2014·European Journal of Medicinal Chemistry·Parvesh SinghVipan Kumar
Mar 9, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Addila Abu BakarSyed Adnan Ali Shah
Mar 21, 2018·Chemistry Central Journal·Siti Noor Hajar ZamrusSyed Adnan Ali Shah
Apr 25, 2019·MedChemComm·Selvaraj ShyamsivappanPalathurai Subramaniam Mohan
Jan 15, 2013·Molecular Diversity·Adile Ayati, Saeed Emami
Apr 17, 2013·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Saeedeh NoushiniAlireza Foroumadi
Aug 30, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sze Wei LeongKhatijah Yusoff
Apr 7, 2020·Current Organic Synthesis·Santosh RautMohammad Arif Pathan
Sep 27, 2019·European Journal of Medicinal Chemistry·Poh Yen KhorKok Wai Lam
Oct 10, 2012·European Journal of Medicinal Chemistry·Rodrigo AboniaJusto Cobo