Asymmetrical and Isolated Hypoglossal Nerve Palsy Accompanied by a New Subset of Anti-ganglioside Antibodies in a Patient with Diffuse Large B Cell Lymphoma

Internal Medicine
Yasuyuki OhtaKoji Abe

Abstract

Malignant lymphoma sometimes involves peripheral nerves due to paraneoplastic syndrome associated with anti-ganglioside antibodies. We report a very rare case of malignant lymphoma accompanied by an asymmetrical and isolated hypoglossal nerve palsy associated with a new subset of anti-ganglioside antibodies. Magnetic resonance imaging and 18F-2-deoxy-2-fluoro-D-glucose position emission tomography showed no abnormalities of the hypoglossal nerve nucleus; however, the patient' s serum was positive for anti-sulfated glucuronyl paragloboside IgM antibodies as well as anti-GM1 IgM and anti-GQ1b IgM antibodies. The present case might suggest a paraneoplastic asymmetrical and isolated hypoglossal nerve palsy associated with a new subset of anti-ganglioside antibodies.

References

Mar 1, 2002·Muscle & Nerve·Yumi SakakibaraNobuhiro Yuki
Nov 22, 2007·Biochimica Et Biophysica Acta·Gustavo A NoresFernando J Irazoqui
Feb 8, 2011·Clinical Neurology and Neurosurgery·Fioravante CaponeSerenella Servidei

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Methods Mentioned

BETA
biopsy
electrophoresis

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