Asymmetrical division of Saccharomyces cerevisiae.

Journal of Bacteriology
P G Lord, A E Wheals

Abstract

The unequal division model proposed for budding yeast (L. H. Hartwell and M. W. Unger, J. Cell Biol. 75:422-435, 1977) was tested by bud scar analyses of steady-state exponential batch cultures of Saccharomyces cerevisiae growing at 30 degrees C at 19 different rates, which were obtained by altering the carbon source. The analyses involved counting the number of bud scars, determining the presence or absence of buds on at least 1,000 cells, and independently measuring the doubling times (gamma) by cell number increase. A number of assumptions in the model were tested and found to be in good agreement with the model. Maximum likelihood estimates of daughter cycle time (D), parent cycle time (P), and the budded phase (B) were obtained, and we concluded that asymmetrical division occurred at all growth rates tested (gamma, 75 to 250 min). D, P, and B are all linearly related to gamma, and D, P, and gamma converge to equality (symmetrical division) at gamma = 65 min. Expressions for the genealogical age distribution for asymmetrically dividing yeast cells were derived. The fraction of daughter cells in steady-state populations is e-alpha P, and the fraction of parent cells of age n (where n is the number of buds that a cell has pro...Continue Reading

Citations

Jan 19, 2000·Molecular Biology of the Cell·K C ChenJ J Tyson
Dec 17, 2008·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Danilo PorroChristos Hatzis
Feb 8, 2013·Proceedings of the National Academy of Sciences of the United States of America·Xin GuoAlexander J Hartemink
Apr 21, 2016·Nature Communications·Pasquale PalumboLilia Alberghina
Jun 21, 2019·BMC Bioinformatics·Mansooreh AhmadianYang Cao
Jan 1, 1983·Annals of the New York Academy of Sciences·J E BaileyF Srienc
Jun 1, 2004·Molecular Biology of the Cell·Katherine C ChenJohn J Tyson
Aug 1, 1983·Biotechnology and Bioengineering·D Vraná
Dec 1, 1993·Biotechnology and Bioengineering·M N PonsJ A Dodds
Jan 8, 2014·Genetics·Steven B Haase, Curt Wittenberg
Feb 2, 2015·Bioinformatics·Theresa NiederbergerAchim Tresch
May 1, 1992·Cell Proliferation·A E Wheals, P G Lord
Mar 1, 1995·Molecular Microbiology·I FishovN B Grover
Aug 27, 2010·Molecular Systems Biology·Debashis BarikJohn J Tyson
May 1, 1983·Biotechnology and Bioengineering·L AlberghinaM Vanoni
Oct 21, 2014·Environmental Microbiology·Christian Dusny, Andreas Schmid
Jun 1, 1996·Canadian Journal of Microbiology·E V Soares, M Mota
Sep 11, 2007·Proceedings of the National Academy of Sciences of the United States of America·Maga RowickaZbyszek Otwinowski
Sep 22, 1994·Nature·L Hartwell
Aug 5, 1988·Biotechnology and Bioengineering·D PorroL Alberghina
Sep 15, 2018·Scientific Reports·Eliezer KeinanYaakov Nahmias
Dec 19, 2003·FEMS Microbiology Letters·Danilo PorroLilia Alberghina
Sep 23, 2000·Journal of Microbiological Methods·D PorroM Vanoni
Jun 1, 1989·Molecular and Cellular Biology·M D BaroniL Alberghina
Dec 1, 1983·Journal of Bacteriology·M VanoniL Alberghina
Nov 1, 1984·Molecular and Cellular Biology·B J BrewerW L Fangman
Apr 1, 1982·Molecular and Cellular Biology·A E Wheals
Jan 1, 1983·Bio Systems·L AlberghinaG Bortolan

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