Asymmetrical involvement of the cerebral neocortex on the response to an immunopotentiator, sodium diethyldithiocarbamate

Journal of Neuroscience Research
G Renoux, K Bizière

Abstract

We have previously shown that the neocortex in mice has a lateralized influence on the immune system. A partial left or bilateral neocortical lesion selectively decreases spleen T-cell numbers and function, natural killer and (NK) activity, but a right neocortical lesion do not affect NK activity, and increases T-cell numbers and T-cell-mediated events. Here we report that the immunopotentiating activity of sodium diethyldithiocarbamate (Imuthiol), a compound that selectively increases T-cell numbers and activities, is dependent on an intact neocortex. The effects of Imuthiol were examined in female C3H/HeJ mice 10 weeks after partial neocortical lesions. In animals with right or bilateral neocortical lesions, Imuthiol failed to increase the percentage of spleen T cells, did not influence the expression of class I MHC antigen on these cells, no longer induced the release in serum of specific T-cell-inducing factors, and failed to enhance T-cell-mediated events. In contrast, in animals with a left neocortical lesion, Imuthiol increased T-cell numbers and activities in a fashion that was comparable to that observed in unlesioned controls, but did not enhance NK activity. It is concluded that Imuthiol may affect immune responsiven...Continue Reading

References

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Citations

Oct 1, 1992·International Journal of Immunopharmacology·O HajouiK Krzystyniak
Jan 1, 2008·Neuromodulation : Journal of the International Neuromodulation Society·Xiao-Yang JiaoKang-Sheng Li
Mar 1, 1988·The International Journal of Neuroscience·G Renoux
Jun 3, 2004·Annals of Neurology·Kimford J MeadorPierre J Neveu

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