Asymmetrical involvement of the cerebral neocortex on the response to an immunopotentiator, sodium diethyldithiocarbamate

Journal of Neuroscience Research
G Renoux, K Bizière


We have previously shown that the neocortex in mice has a lateralized influence on the immune system. A partial left or bilateral neocortical lesion selectively decreases spleen T-cell numbers and function, natural killer and (NK) activity, but a right neocortical lesion do not affect NK activity, and increases T-cell numbers and T-cell-mediated events. Here we report that the immunopotentiating activity of sodium diethyldithiocarbamate (Imuthiol), a compound that selectively increases T-cell numbers and activities, is dependent on an intact neocortex. The effects of Imuthiol were examined in female C3H/HeJ mice 10 weeks after partial neocortical lesions. In animals with right or bilateral neocortical lesions, Imuthiol failed to increase the percentage of spleen T cells, did not influence the expression of class I MHC antigen on these cells, no longer induced the release in serum of specific T-cell-inducing factors, and failed to enhance T-cell-mediated events. In contrast, in animals with a left neocortical lesion, Imuthiol increased T-cell numbers and activities in a fashion that was comparable to that observed in unlesioned controls, but did not enhance NK activity. It is concluded that Imuthiol may affect immune responsiven...Continue Reading


Sep 22, 1978·Science·V H DenenbergR Kaplan
Jan 1, 1986·International Journal of Immunopharmacology·J M GuillauminG Renoux
Jan 1, 1987·Annals of the New York Academy of Sciences·G RenouxD Degenne
Nov 1, 1970·The American Journal of Physiology·N T MacrisM Stein
Jan 1, 1983·Scandinavian Journal of Immunology·G RenouxJ M Guillaumin
Apr 2, 1984·Brain Research· Bakalkin GYaO G Krivosheev
Dec 1, 1983·Journal of Neuroimmunology·G RenouxD Degenne
Jan 1, 1981·Psychopharmacology·S D GlickR C Meibach
Jan 1, 1982·Psychopharmacology·S D GlickR C Meibach
Mar 1, 1982·Journal of the Neurological Sciences·R J CrossW R Markesbery
Jan 1, 1981·Scandinavian Journal of Immunology·P BardosG Renoux
Apr 1, 1985·Immunology Today·J E Blalock, E M Smith

❮ Previous
Next ❯


Oct 1, 1992·International Journal of Immunopharmacology·O HajouiK Krzystyniak
Jan 1, 2008·Neuromodulation : Journal of the International Neuromodulation Society·Xiao-Yang JiaoKang-Sheng Li
Mar 1, 1988·The International Journal of Neuroscience·G Renoux
Jun 3, 2004·Annals of Neurology·Kimford J MeadorPierre J Neveu

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.