Asymmetrical ovarian function during recruitment and selection of the dominant follicle in the menstrual cycle of the rhesus monkey

The Journal of Clinical Endocrinology and Metabolism
G S diZeregaG D Hodgen

Abstract

Despite similar exposure to pituitary gonadotropins by perfusion of both ovaries with the same peripheral blood, only 1 of the 2 ovaries sponsors the single dominant follicle in the typical menstrual cycle. In the present study was examined the initiation of asymmetrical ovarian function during recruitment and selection of the dominant follicle in the primate ovarian cycle by comparison of steroid hormones in the ovarian venous effluent. Thirty-four adult female rhesus monkeys were selected because of high estimated fertility based on their reproductive performance. These monkeys underwent laparotomy for ovarian inspection and collection of ovarian venous blood on 1 of days 1, 3, 5, 7, 9, and 11 after the onset of menses. In addition, femoral blood was collected daily. Repeat laparotomies were performed in the midluteal phase to assess the location of the functional corpus luteum. Concentrations of 17 beta-estradiol, androstenedione, and progesterone were determined in all sera, as well as LH and FSH in peripheral sera, by RIA. In all, 17 of 19 ovulatory monkeys manifested clear asymmetry of 17 beta-estradiol 5 days before the LH/FSH midcycle surges. Often, asymmetry of androstenedione levels was not apparent until 3 days befor...Continue Reading

Citations

Jan 1, 1987·Journal of Steroid Biochemistry·G S diZeregaG Westhof
Feb 1, 1990·British Journal of Obstetrics and Gynaecology·K HataM Kitao
Feb 1, 1987·Baillière's Clinical Endocrinology and Metabolism·D L HealyP A Rogers
Feb 1, 1986·Clinics in Endocrinology and Metabolism·S A Tonetta, G S diZerega
Jan 1, 1988·Annals of the New York Academy of Sciences·A PellicerA H De Cherney
May 1, 1984·The Australian & New Zealand Journal of Obstetrics & Gynaecology·J F KerinL W Cox
Feb 1, 1997·Endocrine Reviews·B C Fauser, A M Van Heusden

Related Concepts

Androstenedione
Estradiol, (16 alpha,17 beta)-Isomer
Follicle Stimulating Hormone
Atretic Follicle
Luteozyman
Macaca mulatta
Menstruation
Ovary
Progesterone, (9 beta,10 alpha)-Isomer

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