Abstract
The signal in balanced steady-state free precession has a strong sensitivity to off-resonance, which is typically described in terms of a signal "profile" over a range of frequencies. This profile has a well-known form for homogeneous media with a single T(1), T(2), and resonance frequency, which is symmetric about the on-resonance frequency. However, a straightforward extension to this established signal model predicts that the profile may become asymmetric in the presence of inhomogeneous frequency content, as would be expected to happen in tissue due to microstructural boundaries, compartments, and chemical shift. The presence of asymmetries in the balanced steady-state free precession profile may therefore provide a marker of tissue integrity. This manuscript describes the theory behind balanced steady-state free precession asymmetries, a method for detecting these effects, and the first measurements of balanced steady-state free precession asymmetries in tissue. Asymmetries are found in gray matter, white matter, and muscle, with excellent reproducibility. A companion paper considers the large white matter asymmetries in more detail.
References
Mar 1, 1993·Biophysical Journal·S OgawaK Ugurbil
May 8, 1999·Journal of Magnetic Resonance Imaging : JMRI·J P WansapuraW S Ball
Nov 5, 1999·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·S S VasanawalaD G Nishimura
Apr 11, 2001·IEEE Transactions on Medical Imaging·Y ZhangS Smith
Jul 10, 2001·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·B A HargreavesD G Nishimura
Aug 23, 2001·Medical Image Analysis·M Jenkinson, S Smith
Sep 11, 2001·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·V S DeshpandeD Li
Dec 18, 2001·NMR in Biomedicine·K SchefflerE M Haacke
Mar 1, 2002·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·William R OverallBob S Hu
Sep 5, 2002·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·D L Foxall
Oct 23, 2002·Human Brain Mapping·Stephen M Smith
Jan 24, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Klaus Scheffler, Jürgen Hennig
Aug 27, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·William R OverallBob S Hu
Oct 3, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Karla L MillerJohn M Pauly
Jan 6, 2004·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Pippa StoreyRobert R Edelman
Jul 6, 2004·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Milica MedvedGregory S Karczmar
Feb 22, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Rohan DharmakumarGraham A Wright
Mar 1, 2005·Magnetic Resonance Imaging·E Mark HaackeAndre Obenaus
Oct 11, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Bernd U FoersterElisabeth C Caparelli
Dec 14, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Karla L MillerJohn M Pauly
Jul 21, 2006·NeuroImage·Tie-Qiang LiJeff Duyn
Sep 2, 2006·NMR in Biomedicine·O Bieri, K Scheffler
Oct 13, 2006·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·O Bieri, K Scheffler
Dec 28, 2006·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Xiang He, Dmitriy A Yablonskiy
Jun 26, 2007·Proceedings of the National Academy of Sciences of the United States of America·Jeff H DuynMasaki Fukunaga
Aug 30, 2008·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Sean FoxleyGregory S Karczmar
Aug 30, 2008·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Karla L Miller, Peter Jezzard
Mar 3, 2009·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Andrea CherubiniGianfranco Spalletta
Citations
Dec 14, 2011·Topics in Magnetic Resonance Imaging : TMRI·Michael M ZeinehRoland Bammer
Feb 11, 2016·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Sarah LarmourRichard B Thompson
Jan 31, 2014·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Thomas BenkertFelix A Breuer
Jun 30, 2015·Zeitschrift für medizinische Physik·Thomas BenkertFelix A Breuer
Nov 3, 2010·NeuroImage·Jongho LeeJeff H Duyn
Sep 9, 2016·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Damien Nguyen, Oliver Bieri
Jul 25, 2017·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Tom HilbertOliver Bieri
Jun 13, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jakob AssländerMartijn A Cloos
Jul 19, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Yulia ShcherbakovaLambertus W Bartels
Sep 5, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Soraya GavazziAstrid L H M W van Lier
Dec 14, 2019·NMR in Biomedicine·Rahel HeuleKlaus Scheffler
Dec 25, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Tobias C WoodShaihan J Malik
Jun 2, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Rahel HeuleKlaus Scheffler
Oct 29, 2015·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Gopal VarmaAaron K Grant
May 26, 2017·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Yulia ShcherbakovaLambertus W Bartels
Aug 13, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Sean FoxleyNarayanan Kasthuri
Oct 12, 2018·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Yulia ShcherbakovaLambertus W Bartels
Apr 12, 2012·Materials·Hyung Joon ChoYiqiao Song
Oct 28, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Santhosh IyyakkunnelOliver Bieri
Aug 28, 2021·Scientific Reports·Gyula KotekJuan A Hernandez-Tamames
Nov 15, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jessica SchäperOliver Bieri