Asymmetry of basal ganglia glucose metabolism and dopa responsiveness in parkinsonism

Movement Disorders : Official Journal of the Movement Disorder Society
S DethyS Goldman

Abstract

We investigated, by positron emission tomography (PET) with [18F]fluoro-2-deoxy-d-glucose (FDG) (FDG-PET), brain glucose metabolism in 19 patients with parkinsonian features. We compared local pattern of FDG uptake and asymmetry indexes in patients with therapeutic response to levodopa (L-dopa) (group 1, presumed Parkinson's disease, n = 9) and patients without L-dopa therapeutic response (group 2, presumed striatonigral degeneration, n = 10). Limb dystonia was present in 11% of patients in group 1 and in 40% of patients in group 2. Asymmetry in basal ganglia metabolism was distributed differently in the two groups (analysis of variance, p < 0.04). In superior and inferior putamen, superior and middle caudate, ventral striatum, and inferior thalamus, relative reduction in metabolism on the side contralateral to predominant parkinsonian signs was associated with L-dopa unresponsiveness. On the contrary, in middle caudate, ventral striatum, and inferior thalamus, a relative increase in metabolism on the side contralateral to the predominant side, parkinsonian signs were found in L-dopa-responsive patients. Our FDG-PET study using simple statistical procedures demonstrates inverse asymmetry of basal ganglia glucose metabolism in p...Continue Reading

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Citations

Jul 12, 2002·Movement Disorders : Official Journal of the Movement Disorder Society·Giulio CicarelliPaolo Barone
Oct 3, 2002·Movement Disorders : Official Journal of the Movement Disorder Society·Brad A RacetteJoel S Perlmutter
Dec 29, 2000·Clinical Nuclear Medicine·R TatlidilH Mayberg
Jun 16, 2004·Movement Disorders : Official Journal of the Movement Disorder Society·Elan D LouisEva C Jurewicz
Feb 13, 2002·Seminars in Nuclear Medicine·Andrew NewbergMartin Reivich
Feb 8, 2005·Radiologic Clinics of North America·Andrew B Newberg, Abass Alavi
Nov 24, 2016·Journal of Neural Transmission·Rastislav ŠumecMartin Bareš
Jan 11, 2014·Therapeutic Advances in Neurological Disorders·Jack J Chen, Laura Marsh
Apr 16, 2013·Journal of Geriatric Psychiatry and Neurology·Erica HarrisRaymon Durso
Nov 6, 2017·Brain Structure & Function·Justin N WeilnauRehana K Leak
Apr 4, 2020·Journal of Geriatric Psychiatry and Neurology·Amitha DhingraAdriana P Hermida
Apr 30, 2017·Clinical Gerontologist·Nadeeka N W DissanayakaNancy A Pachana
Apr 16, 2018·Cell and Tissue Research·P RiedererR Krüger

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