Asymmetry of Cerebral Peduncles for Predicting Motor Function Restoration in Young Patients Before Hemispherectomy

World Neurosurgery
Xiuyu DuGuoming Luan

Abstract

Hemispherectomy has been used successfully for patients with medically intractable epilepsy. However, it is difficult to predict postoperative motor function. The aim of the present study was to analyze whether the preoperative asymmetry of cerebral peduncles could be used to predict motor function restoration before hemispherectomy for young patients with medically intractable epilepsy. The clinical record and magnetic resonance imaging data of 53 patients were analyzed retrospectively. The correlation between preoperative cerebral peduncle asymmetry ratio (pCPAR) and pre- and postoperative changes in motor function was evaluated, as well as the influencing factors for pCPAR, such as duration and etiology factors. The restoration of motor function was defined as changes in pre- and postoperative hemiparesis. The pCPARs of patients with improved and unchanged hemiparesis were significantly greater than that of worsened patients. Patients with a pCPAR of more than 1.5 had an obvious restorative capacity of motor function of the intact hemisphere, and these patients had a lower risk of worsening hemiparesis. The duration in the improved/unchanged and worsened groups was 5.84 ± 3.85 years and 2.67 ± 2.03 years, respectively. Furth...Continue Reading

References

Jul 1, 1996·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·W J PeacockH V Vinters
Jan 8, 1999·Pediatric Neurology·C J GravelineP A Hwang
Jul 9, 2004·Brain : a Journal of Neurology·R van EmpelenUNKNOWN Dutch Collaborative Epilepsy Surgery Programme
Jul 1, 2006·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·K N FountasC Di Rocco
Sep 15, 2006·Journal of Child Neurology·Hiroyuki WakamotoHarry T Chugani
Mar 21, 2007·Neurorehabilitation and Neural Repair·Stella de BodeBruce Dobkin
Aug 5, 2010·Pediatric Neurology·Rajkumar Munian GovindanSandeep Sood
Sep 15, 2012·Epilepsy Research·Nicolien M van der KolkKees P J Braun
Oct 12, 2013·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Chun-Hsien LinMing-Hsueh Lee
Jul 29, 2015·Seizure : the Journal of the British Epilepsy Association·Cecilia VerdinelliKristina Malmgren
Aug 28, 2016·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Fatima Yousif IsmailMichael V Johnston

❮ Previous
Next ❯

Citations

Dec 19, 2020·Translational Neuroscience·Yu-Hui LiBu-Lang Gao
Mar 17, 2019·World Neurosurgery·Alvin Y ChanSumeet Vadera

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.