PMID: 7542916Jun 1, 1995Paper

Asymmetry of disciform scarring in bilateral disease when one eye is treated with radiotherapy

The British Journal of Ophthalmology
P M HartU Chakravarthy

Abstract

A previous study has shown that in age-related macular degeneration a high degree of concordance of disciform scar size occurs in the two eyes of any one patient. In a study of 35 patients with choroidal neovascular membrane who were treated with low dose ionising radiation to the macula of the affected eye, 11 were found to have bilateral disease. The visual outcome and scar size and morphology in the two eyes of each of these patients were compared. In all radiotherapy treated eyes the appearance of the scar ranged from subtle subretinal pigmentary changes to dense subretinal fibrosis. By contrast all untreated fellow eyes showed marked subretinal scarring. Scars in radiotherapy treated eyes occupied an area that was approximately one third of that in untreated fellow eyes (3.8 mm2 v 11.7 mm2). Distance and near visual acuities in radiotherapy treated eyes were significantly better than that of untreated fellow eyes (p < 0.0033). Although untreated fellow eyes of necessity had longer follow up periods (64.5 months), the mean follow up time in treated eyes was 28 months by which time the disciform response is generally thought to have ceased evolving. This study has provided evidence in support of reduced scarring and maintena...Continue Reading

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Citations

May 20, 1999·American Journal of Ophthalmology·D H CharS Kroll
Oct 31, 1998·Harvard Women's Health Watch
Dec 22, 1999·Ophthalmology·R F SpaideJ A Sorenson
Nov 1, 1996·International Journal of Radiation Oncology, Biology, Physics·J FreireR Unda
Aug 1, 1997·International Journal of Radiation Oncology, Biology, Physics·K SasaiM Hiraoka
Nov 22, 1997·International Journal of Radiation Oncology, Biology, Physics·L W BradyR H Sagerman
Apr 8, 1998·International Journal of Radiation Oncology, Biology, Physics·M AkmansuM Or
Dec 9, 2003·The British Journal of Ophthalmology·P T FingerA Szechter
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Sep 15, 2012·International Journal of Radiation Oncology, Biology, Physics·Amar U KishanPercy Lee
Nov 9, 2004·American Journal of Ophthalmology·Dennis M MarcusUNKNOWN AMDRT Research Group
Oct 1, 2003·Clinical & Experimental Ophthalmology·Claire Y Hooper, Robyn H Guymer
Jun 10, 2000·Seminars in Ophthalmology·O Gelisken, B Yazici
Mar 1, 2016·International Journal of Particle Therapy·Stephanie R RiceMinesh P Mehta
Oct 8, 1998·Survey of Ophthalmology·T A CiullaA Harris
Jan 27, 1998·Ophthalmology·R F SpaideD Abramson

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