PMID: 6824664Mar 9, 1983Paper

Asymmetry of glucose transport in the yeast, Kluyveromyces lactis

Biochimica Et Biophysica Acta
P W Royt


Uptake and efflux of 6-deoxy-D-[3H]glucose and of 2-deoxy-D-[14C]glucose by the yeast Kluyveromyces lactis was studied. The tritiated, nonphosphorylatable hexose analogue leaves the cell in the absence and presence of intracellular 2-deoxy-D-glucose 6-phosphate. In energy-rich cells containing pools of hexose 6-phosphate, 2-deoxy-D-glucose is trapped in the cells, for it neither effluxes into glucose-free medium nor exchanges with external, free sugar. In starved, poisoned cells containing negligible amounts of 2-deoxy-D-glucose 6-phosphate, 2-deoxy-D-glucose does leave the cells upon transfer to glucose-free medium. An involvement of analogue structure and availability of metabolites of energy-rich cells in hexose retention is suggested. An internal pool of 6-deoxy-D-glucose does not affect the rate of uptake of 6-deoxy-D-[3H]glucose, nor does internal 2-deoxy-D-[14C]glucose 6-phosphate influence that rate. Hence, transport of glucose by this yeast is probably not regulated by internal pools of glucose 6-phosphate.


Jan 1, 1979·Antonie van Leeuwenhoek·P W Royt, A M MacQuillan
Apr 1, 1975·Canadian Journal of Microbiology·M J Zmijewski, A M MacQuillan
Mar 5, 1976·Biochimica Et Biophysica Acta·P W Royt, A M MacQuillan
Mar 26, 1964·Biochemical and Biophysical Research Communications·E VINUELAA SOLS
May 7, 1982·Biochimica Et Biophysica Acta·P W Royt
Sep 1, 1954·Journal of Bacteriology·S SPIEGELMAN, H O HALVORSON
Apr 23, 1965·Biochemical and Biophysical Research Communications·M L SALASA SOLS

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