Asymptomatic carotid lesions and aging: Role of hypertension and other traditional and emerging risk factors

Archives of Medical Research
Glauco MilioSalvatore Novo

Abstract

We evaluated the prevalence of intima-media thickening (IMT) and asymptomatic carotid plaque (ACP) in a group of subjects with or without traditional and/or emerging risk factors (RF). There were 631 subjects (313 male and 318 female) aged between 19 and 97 years, asymptomatic for cerebro- and cardiovascular diseases. The following measurements were used: anamnesis, physical examination, height and sitting blood pressure. Biochemistry variables were also considered: total cholesterol, HDL-C, LDL-C, triglycerides, fibrinogen, high sensitive C-reactive protein, IgG antibodies for Helicobacter pylori (HP), cytotoxic HP, cytomegalovirus and Chlamydia pneumoniae. Finally, an echo color Doppler examination of the carotid arteries was performed. We subdivided the population studied in normotensive and hypertensive subjects and evaluated in each group the frequency of IMT and ACP in relation to age. We showed that IMT + ACP was significantly more frequent in patients >65 years in comparison with those <65 years (80.6 vs. 52.1%, p < 0.005) and in hypertensive patients in comparison to normotensive, independent of coexistence of other cardiovascular risk factors (71 vs. 48%, p < 0.005). Another interesting result of our study is a signif...Continue Reading

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Citations

Feb 16, 2010·Aging Clinical and Experimental Research·Giorgio AnnoniCarlo Vergani
Jun 3, 2006·Archives of Medical Research·Mohammed AbbasFrancesco Corea
Sep 7, 2016·Annals of Medicine·Jaroslav PelisekHans-Henning Eckstein

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