Asymptomatic hyperuricemia and serum uric acid concentration correlate with subclinical atherosclerosis in psoriatic arthritis patients without clinically evident cardiovascular disease

Seminars in Arthritis and Rheumatism
Miguel A González-GayJavier Llorca

Abstract

To establish whether serum uric acid concentration correlates with carotid intima-media wall thickness (IMT) in a cohort of psoriatic arthritis (PsA) patients without overt cardiovascular (CV) disease or classic CV risk factors who attended a community hospital. A series of 52 PsA patients were assessed by carotid ultrasonography. Carotid IMT and carotid plaques were measured in the right common carotid artery. A correlation between serum uric acid concentration and carotid IMT was assessed and receiver operating characteristic curves to evaluate the ability of serum uric acid to predict carotid IMT > 0.90 mm and carotid plaques were performed. PsA patients with hyperuricemia (n = 6 [11.5%]) had greater carotid IMT (mean +/- standard deviation: 0.89 +/- 0.20 mm) than those without hyperuricemia (n = 46 [89%]; 0.67 +/- 0.16 mm) (P = 0.01). Patients with carotid IMT < 0.60 mm had lower mean serum uric acid levels (4.7 +/- 1.2 mg/dL) than those with greater carotid IMT (5.3 +/- 1.7 mg/dL for patients with carotid IMT 0.76-0.90 mm and 6.4 +/- 1.3 mg/dL for those with carotid IMT > 0.90 mm; P for trend = 0.02). A significant correlation between carotid IMT and serum uric acid concentration was observed (r = 0.337; P = 0.01). High se...Continue Reading

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Citations

Apr 3, 2014·ISRN Rheumatology·Laura BillietManuel T Velasquez
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