PMID: 9527148Apr 4, 1998Paper

Asymptomatic spinal cord lesions in clinically isolated optic nerve, brain stem, and spinal cord syndromes suggestive of demyelination

Journal of Neurology, Neurosurgery, and Psychiatry
J I O'RiordanD Miller

Abstract

Conventional T2 weighted MRI studies have highlighted the fact that the presence of clinically silent brain lesions increases the risk of developing clinically definite multiple sclerosis after an isolated syndrome of the optic nerve, brain stem, or spinal cord. The objectives of the present study are: (1) to show whether or not these patients also have asymptomatic abnormalities of the spinal cord, and (2) to recruit a new cohort of such patients using high resolution MRI of both brain and spinal cord. The brain was imaged in the axial plane with 3 mm thick contiguous slices using a proton density and T2 weighted fast spin echo (FSE) sequence; a T1 weighted sequence after the injection of gadolinium-DTPA; and a fast fluid attenuated inversion recovery (fFLAIR) sequence. The spinal cord was imaged in the sagittal plane with 3 mm thick slices using a T2 weighted FSE and a T1 weighted gadolinium enhanced sequence. Thirty three patients, mean age 31 (16-46) were recruited. There were 14 men and 19 women. Brain MRI was abnormal in 22 (67%); no patient was seen with abnormalities on only one or other sequence. Six patients (18%) displayed one or more gadolinium enhancing lesions on brain MRI. In the spinal cord, nine (27%) patients ...Continue Reading

References

Sep 1, 1978·Brain : a Journal of Neurology·D A CompstonW I McDonald
Jan 1, 1992·Neurology·B FordG Francis
Feb 1, 1992·Acta Neurologica Scandinavica·P ChristiansenH B Larsson
Sep 1, 1991·Acta Neurologica Scandinavica·V MartinelliN Canal
Apr 1, 1990·Annals of Neurology·M Sandberg-WollheimL P Ryder
Feb 1, 1988·Journal of the Neurological Sciences·A L Hume, S G Waxman
Dec 1, 1988·Journal of Neurology, Neurosurgery, and Psychiatry·D H MillerI F Moseley
Dec 1, 1987·Annals of Neurology·D H MillerI F Moseley
Jun 1, 1987·Journal of Neurology, Neurosurgery, and Psychiatry·D A FrancisW I McDonald
Jul 1, 1986·Journal of Neurology, Neurosurgery, and Psychiatry·I E OrmerodI F Moseley
Feb 1, 1986·Journal of Neurology, Neurosurgery, and Psychiatry·I E OrmerodE Peringer
May 6, 1972·Lancet·A M HallidayJ Mushin
Feb 1, 1968·Journal of Neurology, Neurosurgery, and Psychiatry·W G Bradley, C W Whitty
Mar 1, 1983·Annals of Neurology·C M PoserW W Tourtellotte
Jan 1, 1993·European Neurology·S P MorrisseyW I McDonald
Jun 1, 1996·Brain : a Journal of Neurology·J W ThorpeD H Miller
Apr 1, 1996·Journal of Neurology, Neurosurgery, and Psychiatry·J I O'RiordanD H Miller

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Citations

Jun 10, 2010·Clinical Neuroradiology·E HattingenS Weidauer
Nov 11, 2006·Der Radiologe·G Schulte-AltedorneburgW Reith
Aug 10, 2011·Der Radiologe·F J AhlhelmJ Kelm
Feb 13, 2001·Journal of the Neurological Sciences·M RovarisM Filippi
Dec 22, 1999·Journal of the Neurological Sciences·M Rovaris, M Filippi
Dec 22, 1999·Journal of the Neurological Sciences·T A YousryM Filippi
Aug 28, 2003·Lancet Neurology·Geert LycklamaFrederik Barkhof
Jan 6, 2005·The Neurologist·Adam I KaplinDouglas A Kerr
Jul 12, 2008·The Neurologist·Catherine A Kernich
Dec 22, 1999·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·K J Smith, W I McDonald
Dec 22, 1999·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·D H Miller, A J Thompson
Mar 20, 1999·Journal of Neurology, Neurosurgery, and Psychiatry·C LiuL D Blumhardt
Oct 16, 1999·Journal of Neurology, Neurosurgery, and Psychiatry·R N HeardG J Stewart
Jan 22, 2005·Annual Review of Medicine·Jingwu Zhang, George Hutton
Jun 3, 2014·Journal of the Neurological Sciences·Georgina Arrambide, Jaume Sastre-Garriga
Apr 17, 2015·Multiple Sclerosis and Related Disorders·Lucy A Matthews, Jacqueline A Palace
Apr 27, 2010·Clinical Neurology and Neurosurgery·Mohammad Ali Sahraian, Arman Eshaghi
Dec 10, 2008·Neuroimaging Clinics of North America·Joseph C J Bot, Frederik Barkhof
Aug 8, 2008·Journal of the Neurological Sciences·Viviana NocitiLuca Padua
Apr 12, 2007·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Federica Agosta, Massimo Filippi
Jun 15, 2012·Journal of Magnetic Resonance Imaging : JMRI·René M VigevenoFrederik Barkhof
Jan 22, 2005·Neurologic Clinics·Fred D Lublin
Jul 17, 2014·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Wallace J Brownlee, David H Miller
May 27, 2015·Nature Reviews. Neurology·Hugh KearneyOlga Ciccarelli
Jul 28, 2016·Multiple Sclerosis and Related Disorders·Stefania GalassiCarlo Pozzilli
Apr 25, 2012·Multiple Sclerosis : Clinical and Laboratory Research·Barbara KornekKevin Rostasy
Aug 3, 2016·Multiple Sclerosis : Clinical and Laboratory Research·W J BrownleeD H Miller
Feb 9, 2016·Multiple Sclerosis Journal - Experimental, Translational and Clinical·E D'AmicoM Zappia
Jan 10, 2018·Multiple Sclerosis : Clinical and Laboratory Research·Wallace J Brownlee
Mar 17, 2017·Multiple Sclerosis : Clinical and Laboratory Research·Georgina ArrambideMar Tintore
Jul 13, 2018·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Ethan MeltzerTeresa C Frohman
Mar 29, 2014·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·João LemosLuís Cunha

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