Asymptomatic Visceral Leishmania infantum Infection in US Soldiers Deployed to Iraq

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Rupal M ModyNaomi E Aronson

Abstract

Visceral leishmaniasis (VL), due to Leishmania infantum, is a persistent intracellular parasitic infection transmitted by the bite of infected sand flies. Symptomatic VL has been reported in U.S. soldiers with Iraq deployment. Untreated symptomatic VL can be fatal; asymptomatic VL (AVL) may establish a lifelong risk of reactivation. We report prevalence and AVL risk factors in Operation Iraqi Freedom (OIF) deployers during 2002-11. Healthy soldiers exposed to VL endemic areas in Iraq and 50 controls who never traveled to endemic regions were recruited through military healthcare facilities (2015-17). Responses to a risk factor survey and blood samples were obtained. Leishmania research diagnostics utilized included enzyme-linked immunosorbent assay (ELISA), rk39 test strips, quantitative polymerase chain reaction (PCR), and interferon gamma release (IGRA) assays. Statistical analyses included Fisher exact test, Pearson χ2 test, Mann-Whitney U test, and logistic regression. 200 deployed subjects were enrolled, mostly males (84.0%), of white ethnicity (79.0%), and median age 41 (range 24-61) years. 64% were seropositive for Phlebotomus alexandri saliva antibodies. Prevalence of AVL (any positive test result) was 39/200 (19.5%, 95...Continue Reading

References

Nov 1, 1992·The Journal of Infectious Diseases·T G EvansR D Pearson
Oct 1, 1986·The Journal of Infectious Diseases·R BadaróW D Johnson
May 13, 1993·The New England Journal of Medicine·A J MagillC N Oster
Feb 24, 1999·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·A Meyerhoff
Sep 30, 1999·Parasitology·C R Davies, A S Mazloumi Gavgani
Mar 18, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·S M JeronimoT G Evans
Nov 6, 2004·Journal of Clinical Microbiology·Charles MaryHenri Dumon
Dec 4, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Peter J WeinaNaomi E Aronson
Sep 13, 2006·Transfusion·Lisa J Cardo
Sep 20, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Naomi E AronsonKimberly A Moran
Apr 21, 2007·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·A HarringtonA Limaye
Jul 6, 2007·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·M WeisserU Flückiger
Sep 18, 2007·Transactions of the Royal Society of Tropical Medicine and Hygiene·Petros KopteridesMatthew E Falagas
Mar 28, 2008·Transactions of the Royal Society of Tropical Medicine and Hygiene·Luciana de Gouvêa VianaAna Rabello
Jun 16, 2009·Emerging Infectious Diseases·Ioannis D XynosNikolaos V Sipsas
May 14, 2010·Revista Da Sociedade Brasileira De Medicina Tropical·Janaina Michelle de OliveiraAna Lúcia Lyrio de Oliveira
Sep 3, 2010·The American Journal of Tropical Medicine and Hygiene·Roshan K TopnoPradeep Das
Feb 5, 2011·The American Journal of Tropical Medicine and Hygiene·Luciana Almeida SilvaAluízio Prata
Jul 13, 2011·Nature Reviews. Microbiology·Paul Kaye, Phillip Scott
Jul 7, 2012·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·W PoepplJ Walochnik
Sep 4, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jane CunninghamUNKNOWN WHO/TDR Visceral Leishmaniasis Laboratory Network
Dec 29, 2012·PLoS Neglected Tropical Diseases·Letícia Helena dos Santos MarquesMariângela Carneiro
Apr 9, 2013·Revista Do Instituto De Medicina Tropical De São Paulo·Luciana Almeida SilvaAluízio Prata
Aug 10, 2013·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·P Zanger, S Gabrysch
Nov 19, 2013·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·A C VallurS G Reed
Jan 24, 2014·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·J van GriensvenJ Moreno
Mar 4, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Om Prakash SinghShyam Sundar
Feb 1, 2015·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·W ClementeJ Torre-Cisneros
Feb 5, 2016·Journal of Parasitology Research·Om Prakash Singh, Shyam Sundar
Mar 5, 2016·Parasites & Vectors·Vasco RodriguesJérôme Estaquier
Apr 14, 2016·Vector Borne and Zoonotic Diseases·Zuinara MaiaRoberto Badaro
Aug 5, 2016·PLoS Neglected Tropical Diseases·Siddhivinayak HirvePiero Olliaro
Dec 13, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Naomi AronsonAlan Magill

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Citations

Oct 7, 2020·Pathogens·Ahyun HongMaria Fernanda Laranjeira-Silva
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Nov 16, 2021·Journal of the American Veterinary Medical Association·Lauren M SealSheldon G Waugh

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