Asynchronous action potential discharge in human muscle sympathetic nerve activity

American Journal of Physiology. Heart and Circulatory Physiology
Stephen A KlassenJ Kevin Shoemaker

Abstract

What strategies are employed by the sympathetic system to communicate with the circulation? Muscle sympathetic nerve activity (MSNA) occurs in bursts of synchronous action potential (AP) discharge, yet whether between-burst asynchronous AP firing exists remains unknown. Using multiunit microneurography and a continuous wavelet transform to isolate APs, we studied AP synchronicity within human MSNA. Asynchronous APs were defined as those which occurred between bursts. Experiment 1 quantified AP synchronicity in eight individuals at baseline (BSL), -10 mmHg lower body negative pressure (LBNP), -40 mmHg LBNP, and end-expiratory apnea (APN). At BSL, 33 ± 12% of total AP activity was asynchronous. Asynchronous discharge was unchanged from BSL (67 ± 37 AP/min) to -10 mmHg LBNP (69 ± 33 AP/min), -40 mmHg LBNP (83 ± 68 AP/min), or APN (62 ± 39 AP/min). Across all conditions, asynchronous AP probability and frequency decreased with increasing AP size. Experiment 2 examined the impact of the ganglia on AP synchronicity by using nicotinic blockade (trimethaphan). The largest asynchronous APs were derecruited from BSL (11 ± 4 asynchronous AP clusters) to the last minute of the trimethaphan infusion with visible bursts (7 ± 2 asynchronous A...Continue Reading

References

Jan 1, 1972·Acta Physiologica Scandinavica·W DeliusB G Wallin
Jun 1, 1982·The Journal of Physiology·L Y Jan, Y N Jan
Dec 15, 1994·The Journal of Physiology·V G MacefieldA B Vallbo
Nov 18, 1997·Clinical and Experimental Pharmacology & Physiology·R M McAllen, S C Malpas
Sep 2, 1998·Progress in Neurobiology·S C Malpas
Jun 28, 2000·Journal of the Autonomic Nervous System·I L GibbinsJ L Morris
Mar 2, 2002·Autonomic Neuroscience : Basic & Clinical·Vaughan G MacefieldB Gunnar Wallin
Jul 10, 2003·European Journal of Applied Physiology·Johannes J van LieshoutKarel H Wesseling
Feb 28, 2007·Clinical and Experimental Pharmacology & Physiology·Michael P Gilbey
Sep 14, 2010·Journal of Neuroscience Methods·Aryan SalmanpourJ Kevin Shoemaker
Oct 13, 2010·The Journal of Physiology·Craig D SteinbackJ Kevin Shoemaker
Mar 25, 2011·Journal of Neurophysiology·Aryan SalmanpourJ Kevin Shoemaker
Mar 24, 2012·Journal of Neurophysiology·Aryan Salmanpour, J Kevin Shoemaker
Jul 16, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Philip J MillarJohn S Floras
May 8, 2015·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Mark B BadrovJ Kevin Shoemaker
Jan 13, 2016·Comprehensive Physiology·J K ShoemakerD N Jackson
Aug 21, 2016·American Journal of Physiology. Heart and Circulatory Physiology·Mark B BadrovJ Kevin Shoemaker
Oct 28, 2016·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Mark B BadrovJ Kevin Shoemaker
Apr 2, 2017·American Journal of Physiology. Heart and Circulatory Physiology·Emma C HartJohn W Osborn
Aug 25, 2017·Journal of Neurophysiology·Mark B BadrovJ Kevin Shoemaker
Nov 17, 2017·Journal of Neurophysiology·Vaughan G Macefield, B Gunnar Wallin
Dec 8, 2017·Journal of Applied Physiology·Stephen A KlassenJ Kevin Shoemaker
Jul 29, 2018·The Journal of Physiology·Stephen A KlassenJ Kevin Shoemaker
Jul 31, 2018·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Baraa K Al-Khazraji, J Kevin Shoemaker

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Citations

Feb 25, 2020·The Journal of Physiology·Stephen A KlassenJ Kevin Shoemaker
Apr 9, 2020·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Elizabeth P OttJacqueline K Limberg
Jun 27, 2020·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Vaughan G Macefield
Jan 21, 2021·Seminars in Cell & Developmental Biology·Stephen A KlassenSarah E Baker

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