PMID: 45781Jan 1, 1978

Asynchronous termination of plasma membrane protein synthesis in erythroid cells

Membrane Biochemistry
L L ChanR I Sha'afi

Abstract

In this study we focused our attention on the terminal stages of cellular differentiation and asked the question whether the turning off of gene activity is via a general mechanism whereby all proteins are turned off synchronously, or if it is regulated specifically. We examined this problem by measuring the relative rates of synthesis of the plasma membrane proteins in cells that are near the final stages of erythroid differentiation. Our results show that although the rates of synthesis of all proteins decline during maturation the relative rates of decline are different among the various membrane proteins, indicating that the termination of plasma membrane protein synthesis during terminal differentiation is asynchronous.

References

Mar 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·L L Chan
Oct 20, 1978·Deutsche medizinische Wochenschrift·J Benedum, M Weise
Jan 1, 1976·Annual Review of Biochemistry·V T MarchesiM Tomita
Sep 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·H ChangH F Lodish
May 1, 1975·Biochimica Et Biophysica Acta·P A KochJ R Carter
Aug 15, 1975·European Journal of Biochemistry·R A Laskey, A D Mills
Oct 25, 1973·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·G A Bruns, V M Ingram
Jul 1, 1974·The Journal of Cell Biology·T L Steck
May 14, 1972·Journal of Molecular Biology·T L Steck

Citations

Jan 1, 1992·Critical Reviews in Biotechnology·M Mattey

Related Concepts

Cell Differentiation Process
Chick Embryo
Red Cell Ghost
Erythrocytes
Leucine
Cell Surface Proteins

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