At the centre of neuronal, synaptic and axonal pathology in murine prion disease: degeneration of neuroanatomically linked thalamic and brainstem nuclei

Neuropathology and Applied Neurobiology
Renata ReisColm Cunningham

Abstract

The processes by which neurons degenerate in chronic neurodegenerative diseases remain unclear. Synaptic loss and axonal pathology frequently precede neuronal loss and protein aggregation demonstrably spreads along neuroanatomical pathways in many neurodegenerative diseases. The spread of neuronal pathology is less studied. We previously demonstrated severe neurodegeneration in the posterior thalamus of multiple prion disease strains. Here we used the ME7 model of prion disease to examine the nature of this degeneration in the posterior thalamus and the major brainstem projections into this region. We objectively quantified neurological decline between 16 and 18 weeks post-inoculation and observed thalamic subregion-selective neuronal, synaptic and axonal pathology while demonstrating relatively uniform protease-resistant prion protein (PrP) aggregation and microgliosis across the posterior thalamus. Novel amyloid precursor protein (APP) pathology was particularly prominent in the thalamic posterior (PO) and ventroposterior lateral (VPL) nuclei. The brainstem nuclei forming the major projections to these thalamic nuclei were examined. Massive neuronal loss in the PO was not matched by significant neuronal loss in the interpolar...Continue Reading

References

Feb 1, 1992·Neuropathology and Applied Neurobiology·A MigheliD Schiffer
Jun 1, 1987·Microbial Pathogenesis·R H KimberlinC A Walker
Jan 1, 1973·Journal of Comparative Pathology·H Fraser, A G Dickinson
Jul 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·D L PriceS S Sisodia
Jul 1, 1995·Brain Pathology·A GieseH A Kretzschmar
Apr 23, 2003·The American Journal of Pathology·Bing ZhuMax S Cynader
Jun 6, 2003·The European Journal of Neuroscience·C CunninghamV H Perry
Nov 26, 2003·Experimental Neurology·Ronald K H Liem, Conrad L Leung
Jun 4, 2005·Acta Neuropathologica·Yasushi IwasakiGen Sobue
Dec 13, 2005·Methods in Enzymology·James LoweR John Mayer
Jan 10, 2006·Brain : a Journal of Neurology·Pietro CortelliPierluigi Gambetti
Mar 9, 2006·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Masayuki ShintakuKatsumi Doh-ura
Mar 7, 2007·Trends in Neurosciences·Laura ConfortiMichael P Coleman
Jun 8, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Martin FuhrmannJochen Herms
Dec 20, 2007·Journal of Neuropathology and Experimental Neurology·Sanna PartanenJaana Tyynelä
Jul 22, 2008·Nature Reviews. Neuroscience·Mathew E DiamondEhud Ahissar
Dec 9, 2008·Brain : a Journal of Neurology·Robert AdalbertMichael P Coleman
Feb 20, 2009·Nature·Anatoly NikolaevMarc Tessier-Lavigne
Sep 4, 2009·Brain Pathology·Vladimir KepeJorge R Barrio
Jan 8, 2010·Journal of Neurophysiology·Akio Hirata, Manuel A Castro-Alamancos
Feb 25, 2010·Nature Reviews. Neuroscience·Reha S ErzurumluFilippo M Rijli
Mar 20, 2010·Biochemical Society Transactions·Ayodeji A AsuniVincent O'Connor
Mar 24, 2010·Nature Reviews. Molecular Cell Biology·Patrik BrundinRon Kopito
Oct 7, 2011·American Journal of Hypertension·Stephanie S DeLoachBonita Falkner
Jun 20, 2012·The European Journal of Neuroscience·Jana DoehnerIrene Knuesel
Nov 28, 2012·Nature Reviews. Neurology·Dimitrije Krstic, Irene Knuesel
Sep 11, 2013·North American Journal of Medical Sciences·P JayanthiRekha Krishnapillai
Sep 23, 2014·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Daniel H J DavisColm Cunningham

❮ Previous
Next ❯

Methods Mentioned

BETA
confocal microscopy
ubiquitination

Software Mentioned

ImageJ
GraphPad
Cell A
GraphPad Prism
Cell A [UNK]

Related Concepts

Related Feeds

Alzheimer's Disease: APP

Amyloid precursor protein (APP) proteolysis is critical for the development of Alzheimer's disease, a neurodegenerative disease associated with accumulation of amyloid plaques in the brain. Here is the latest research on APP and Alzheimer's disease.