At the Crossroads of Fate-Somatic Cell Lineage Specification in the Fetal Gonad

Endocrine Reviews
Emmi RotgersHumphrey H-C Yao

Abstract

The reproductive endocrine systems are vastly different between males and females. This sexual dimorphism of the endocrine milieu originates from sex-specific differentiation of the somatic cells in the gonads during fetal life. Most gonadal somatic cells arise from the adrenogonadal primordium. After separation of the adrenal and gonadal primordia, the gonadal somatic cells initiate sex-specific differentiation during gonadal sex determination with the specification of the supporting cell lineages: Sertoli cells in the testis vs granulosa cells in the ovary. The supporting cell lineages then facilitate the differentiation of the steroidogenic cell lineages, Leydig cells in the testis and theca cells in the ovary. Proper differentiation of these cell types defines the somatic cell environment that is essential for germ cell development, hormone production, and establishment of the reproductive tracts. Impairment of lineage specification and function of gonadal somatic cells can lead to disorders of sexual development (DSDs) in humans. Human DSDs and processes for gonadal development have been successfully modeled using genetically modified mouse models. In this review, we focus on the fate decision processes from the initial st...Continue Reading

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Citations

Nov 13, 2018·Endocrinology·Halima AlbalushiJan-Bernd Stukenborg
Dec 28, 2018·Endocrine Reviews·Juho-Antti MäkeläJorma Toppari
Aug 2, 2019·Molecular Reproduction and Development·Indrashis BhattacharyaSubeer S Majumdar
Sep 12, 2019·International Journal of Molecular Sciences·Yasmine NeirijnckSerge Nef
Apr 1, 2020·International Journal of Molecular Sciences·Nathalia Lisboa GomesRod T Mitchell
Dec 19, 2019·Frontiers in Endocrinology·Mohamed A Abedel-MajedAndrea S Cupp
Jul 22, 2019·Cellular and Molecular Life Sciences : CMLS·Danielle MonniauxStéphane Fabre
Aug 8, 2020·Proceedings of the National Academy of Sciences of the United States of America·Wanbao Niu, Allan C Spradling
Sep 16, 2020·International Journal of Molecular Sciences·Martin A Estermann, Craig A Smith
Jan 31, 2021·Molecular and Cellular Endocrinology·Xingxing ZhaoHaolin Chen
Jan 6, 2021·Endocrinology and Metabolism·Ken-Ichirou MorohashiTakashi Baba
Feb 12, 2021·Endocrinology·Nathalia de Lima E Martins LaraIna Dobrinski
Apr 24, 2021·Genes & Development·Emily R FrostJessie M Sutherland
May 6, 2021·Human Brain Mapping·Lauren E SalminenPaul M Thompson
Nov 13, 2020·Physiological Reviews·Yoshitaka NagahamaMasaru Nakamura
May 19, 2021·Seminars in Cell & Developmental Biology·Xiaoheng LiRen-Shan Ge
Jul 8, 2021·Seminars in Cell & Developmental Biology·Liza O'DonnellDiane Rebourcet
Aug 28, 2021·Diagnostics·Camelia AlkhzouzDiana Miclea
Sep 14, 2021·Frontiers in Cell and Developmental Biology·Martin A EstermannCraig A Smith
Sep 25, 2021·BMC Biology·Elizabeth OliverJan-Bernd Stukenborg
Oct 15, 2021·Anatomia, histologia, embryologia·Javad SadeghinezhadMargherita De Silva
Dec 2, 2021·The Journal of Clinical Investigation·Cyril DjariAnne-Marie Lefrançois-Martinez

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