PMID: 15342979Sep 3, 2004Paper

Ataxia and secretory diarrhea: two unusual paraneoplastic syndromes occurring concurrently in the same patient with ganglioneuroblastoma

Journal of Pediatric Hematology/oncology
Benjamin GesundheitHelen S L Chan

Abstract

The presence of rare paraneoplastic syndromes, the opsoclonus-myoclonus-ataxia syndrome (OMA), presumably caused by antineuronal antibody production, and diarrhea, caused by vasoactive intestinal peptide (VIP) secreted by neuroblastoma, may strongly signal the presence of neuroblastoma. The authors describe a child who presented with both syndromes concurrently; this has never been described previously in the same patient. However, diagnosis of neuroblastoma was delayed by a workup focused on the prolonged diarrhea rather than the ataxia. The diarrhea resolved after tumor resection, whereas OMA required further therapy. Increased awareness of VIP-secretory diarrhea, especially in an ataxic child, might contribute to an earlier diagnosis of neuroblastoma.

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Citations

Dec 23, 2008·European Journal of Pediatrics·Wei-Qiang ZhangYun Xue
Apr 12, 2008·Gastroentérologie Clinique Et Biologique·C NeuzilletP Ruszniewski
Jan 15, 2009·Pediatric Blood & Cancer·Franck BourdeautUNKNOWN Neuroblastoma Committee of the Société Française des Cancers et Leucémies de l'Enfant et de l'Adolescent
Oct 21, 2014·Case Reports in Oncological Medicine·Patrick L StevensKristen M Snyder
Sep 10, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Benjamin GesundheitReuven Or
Jul 1, 2017·Pediatric Hematology and Oncology·Atif A AhmedMaxine Hetherington
Sep 4, 2021·Journal of Immunological Methods·Gislaine FurlanettoMariana Bohns Michalowski

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