Ataxin-1 regulates proliferation of hippocampal neural precursors

Neuroscience
M AsherM Cvetanovic

Abstract

Polyglutamine expansion in the protein ATAXIN-1 (ATXN1) causes spinocerebellar ataxia type 1 (SCA1), an inherited neurodegenerative disease characterized by motor deficits, cognitive impairment and depression. Although ubiquitously expressed, mutant ATXN1 causes neurodegeneration primarily in the cerebellum, which is responsible for the observed motor deficits. The role of ATXN1 outside of the cerebellum and the causes of cognitive deficits and depression in SCA1 are less understood. In this study, we demonstrate a novel role of ATXN1 in the hippocampus as a regulator of adult neurogenesis. Adult hippocampal neurogenesis is the process of generating new hippocampal neurons and is linked to cognition and mood. We found that loss of ATXN1 causes a decrease in hippocampal neurogenesis in ATXN1 null (Atxn1(-/-)) mice. This decrease was caused by reduced proliferation of neural precursors in the hippocampus of Atxn1(-/-) mice, and persisted even when Atxn1(-/-) hippocampal neural precursors were removed from their natural environment and grown in vitro, suggesting that ATXN1 affects proliferation in a cell-autonomous manner. Moreover, expression of ATXN1 with a pathological polyglutamine (polyQ) expansion in wild-type neural precurs...Continue Reading

References

Jan 5, 2000·Human Brain Mapping·N C AndreasenR D Hichwa
Mar 22, 2002·Neuron·Edwin J Weeber, J David Sweatt
Feb 8, 2003·Journal of Neurology·K BürkJ Dichgans
Jan 26, 2006·Brain : a Journal of Neurology·Jeremy D Schmahmann, David Caplan
Mar 3, 2007·Seminars in Pediatric Neurology·Richard E Lutz
Apr 25, 2007·Nature Reviews. Neuroscience·Karl Herrup, Yan Yang
Jun 30, 2007·Human Molecular Genetics·Robert GooldAntoni Matilla-Dueñas
Sep 6, 2007·The Cerebellum·Katrin Bürk
Sep 12, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Michael A BonaguidiJohn A Kessler
Oct 7, 2008·NeuroImage·Catherine J Stoodley, Jeremy D Schmahmann
Aug 19, 2009·Annals of the New York Academy of Sciences·Dengke K MaHongjun Song
Oct 30, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Wei DengFred H Gage
May 4, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Rebecca D HodgeRobert F Hevner
Sep 18, 2012·Biochimica Et Biophysica Acta·Roland Faigle, Hongjun Song
Sep 3, 2013·The Cerebellum·Leonard F KoziolTadashi Yamazaki
Oct 15, 2013·Journal of Neurology·Roberto FancelluFloriano Girotti
Dec 18, 2013·Cell Communication and Signaling : CCS·Silvia Tapia-GonzálezAmelia Sánchez-Capelo
Mar 13, 2014·Frontiers in Neuroscience·Claudio Giachino, Verdon Taylor
May 8, 2014·Development·Simon M G Braun, Sebastian Jessberger
Jun 7, 2014·Annual Review of Neuroscience·Kimberly M ChristianGuo-li Ming
Jun 20, 2014·Biochemical and Biophysical Research Communications·Xin SuYinghui Fu
Aug 8, 2014·Stem Cells·Mathieu DaynacMarc-André Mouthon
Aug 22, 2014·Human Molecular Genetics·Andreia Neves-CarvalhoPatrícia Maciel
May 20, 2015·ELife·Cristian A Lasagna-ReevesHuda Y Zoghbi

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Citations

Mar 14, 2018·The Journal of Clinical Investigation·Chandrakanth Reddy EdamakantiPuneet Opal
Jul 1, 2020·Journal of Experimental & Clinical Cancer Research : CR·Xiaobai LiuYunhui Liu
Sep 4, 2020·Proceedings of the National Academy of Sciences of the United States of America·Alessandro DidonnaJorge R Oksenberg
Dec 19, 2018·Molecular Autism·Remco T MolenhuisMartien J H Kas
Nov 10, 2018·Current Pharmacology Reports·Yijing ZhouYingwei Mao
Jan 14, 2021·Scientific Reports·Melissa AsherMarija Cvetanovic
Nov 7, 2019·Human Molecular Genetics·Melissa AsherMarija Cvetanovic

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