Ataxin-2 Is Droppin' Some Knowledge.

Neuron
Lindsay A Becker, Aaron D Gitler

Abstract

Ataxin-2 is an RNA-binding protein involved in translation regulation and mutated in neurodegenerative diseases, including ALS. In this issue of Neuron, Bakthavachalu et al. (2018) demonstrate that higher-order ataxin-2 RNA/protein assemblies are necessary for both translation-dependent learning and ALS-associated neurodegeneration in Drosophila.

Citations

Jul 27, 2018·The Journal of Biological Chemistry·Edward Gomes, James Shorter
Nov 12, 2020·Critical Reviews in Biochemistry and Molecular Biology·Joshua L SchwartzGene W Yeo
Apr 4, 2021·International Journal of Molecular Sciences·Zaira M López-JuárezPlinio Guzmán

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