AtCHIP functions as an E3 ubiquitin ligase of protein phosphatase 2A subunits and alters plant response to abscisic acid treatment

The Plant Journal : for Cell and Molecular Biology
Jinhua LuoHong Zhang

Abstract

CHIP proteins are E3 ubiquitin ligases that promote degradation of Hsp70 and Hsp90 substrate proteins through the 26S proteasome in animal systems. A CHIP-like protein in Arabidopsis, AtCHIP, also has E3 ubiquitin ligase activity and has important roles to play under conditions of abiotic stress. In an effort to study the mode of action of AtCHIP in plant cells, proteins that physically interact with it were identified. Like its animal orthologs, AtCHIP interacts with a unique class of ubiquitin-conjugating enzymes (UBC or E2) that belongs to the stress-inducible UBC4/5 class in yeast. AtCHIP also interacts with other proteins, including an A subunit of protein phosphatase 2A (PP2A). This PP2A subunit appears to be a substrate of AtCHIP, because it can be ubiquitylated by AtCHIP in vitro and because the activity of PP2A is increased in AtCHIP-overexpressing plants in the dark or under low-temperature conditions. Unlike the rcn1 mutant, that has reduced PP2A activity due to a mutation in one of the A subunit genes of PP2A, AtCHIP-overexpressing plants are more sensitive to ABA treatment. Since PP2A was previously shown to be involved in low-temperature responses in plants, the low-temperature-sensitive phenotype observed in AtCH...Continue Reading

References

Apr 1, 1997·Genes & Development·S GottesmanM R Maurizi
May 14, 1999·Trends in Biochemical Sciences·T A MillwardB A Hemmings
Oct 12, 1999·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·G L Blatch, M Lässle
Dec 22, 1999·The Plant Journal : for Cell and Molecular Biology·J DeruèreA Delong
Jan 9, 2001·Nature Cell Biology·G C MeachamD M Cyr
Jul 4, 2001·The Journal of Biological Chemistry·S HatakeyamaK I Nakayama
Sep 15, 2001·The Journal of Biological Chemistry·J JiangC Patterson
Oct 5, 2001·Molecular Cell·C M Pickart
Oct 9, 2001·Trends in Plant Science·A BachmairF Eisenhaber
Oct 20, 2001·Trends in Cell Biology·C Wójcik
Jul 13, 2002·Trends in Biochemical Sciences·Douglas M CyrCam Patterson
Dec 1, 1994·Plant Physiology·H. ZhangH. M. Goodman
Oct 26, 2002·Trends in Plant Science·Zach Adam, Adrian K Clarke
Dec 31, 2002·The Journal of Biological Chemistry·Jin ZhouGernot Walter
Jun 1, 1996·Annual Review of Plant Physiology and Plant Molecular Biology·Raymond CholletMarion H. O'Leary
Feb 24, 2005·Annual Review of Plant Biology·Katsura IzuiYasushi Kai

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Citations

Feb 25, 2011·Molecules and Cells·Jae-Hoon Lee, Woo Taek Kim
Apr 19, 2011·Plant Molecular Biology·Ting GaoQi Xie
Oct 22, 2011·Journal of Experimental Botany·Wendy J Lyzenga, Sophia L Stone
Jun 23, 2012·Plant Physiology·Dior R Kelley, Mark Estelle
Sep 14, 2007·Current Opinion in Plant Biology·Sophia L Stone, Judy Callis
Mar 25, 2009·The Plant Journal : for Cell and Molecular Biology·Sabine RaabStefan Hoth
Jan 24, 2007·The Plant Journal : for Cell and Molecular Biology·Guoxin ShenHong Zhang
Jul 10, 2007·The Plant Journal : for Cell and Molecular Biology·Mónica PernasJose J Sánchez-Serrano
Nov 1, 2007·The Plant Journal : for Cell and Molecular Biology·Jasmina KurepaJan A Smalle
Mar 26, 2016·Frontiers in Plant Science·Charles CopelandXin Li
Jul 2, 2010·The Journal of Pathology·Lei SunJun Zhou
Mar 8, 2016·Antioxidants·Moona RahikainenSaijaliisa Kangasjärvi
Aug 8, 2006·Current Opinion in Plant Biology·Alison DeLong
Oct 17, 2014·The Arabidopsis Book·Judy Callis
Jun 19, 2015·Journal of Experimental Botany·Jia WeiGuoxin Shen
Mar 28, 2012·Biochimica Et Biophysica Acta·Dong Wook LeeInhwan Hwang
Jan 12, 2013·Molecular Plant·Liyuan Chen, Hanjo Hellmann
Jun 28, 2011·Plant Signaling & Behavior·Meritxell Antolín-LloveraNarciso Campos
Mar 3, 2011·Plant Signaling & Behavior·Hongxia Liu, Sophia L Stone
Dec 17, 2009·Plant Signaling & Behavior·Silvia Marina PaísDaniela Andrea Capiati
Oct 13, 2009·Molecular Cell·Mei KongCraig B Thompson
Mar 19, 2013·Plant Science : an International Journal of Experimental Plant Biology·Javier Barrero-Gil, Julio Salinas
Jul 13, 2016·Biochemical and Biophysical Research Communications·Yongchang LiuJie Sun

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